吴涛
医学博士，研究员，博士生导师
上海市东方英才计划拔尖人才，上海市青年科技启明星
基本信息
办公电话：021-51322748
电子邮箱：tw827@shutcm.edu.cn or wutao001827@163.com
通讯地址：上海市浦东新区蔡伦路1200号2号楼2311室
研究方向
中医药防治慢性肝病的基础与临床研究
招生专业
院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
交叉科学研究院 | 医学 | 中医学 | 100506/中医内科学 | 学术学位 | 博士 |
交叉科学研究院 | 医学 | 中医学 | 100506/中医内科学 | 学术学位 | 硕士 |
教育及任职经历
2021/01-至今，上海中医药大学，交叉科学研究院，研究员
2016/11-2017/04，上海交通大学附属第六人民医院，转化医学研究中心，访问学者
2015/01-2020/12，上海中医药大学，交叉科学研究院，副研究员
2013/11-2014/10，美国夏威夷大学，癌症研究中心，访问学者
2009/12-2014/12，上海中医药大学，中医方证与系统生物学研究中心，助理研究员
2008/08-2009/11，上海中医药大学，中医方证与系统生物学研究中心，研究实习员
2010/09 - 2015/07，上海中医药大学，中医内科学，博士
2005/09 - 2008/07，上海中医药大学，中医内科学，硕士
1997/09 - 2002/07，江西中医学院，中西医结合，学士
近五年以第一负责人承担的科研课题与经费
序号 | 项目来源 | 项目名称 | 起止时间 | 经费(万元) |
1 | 国家自然科学基金面上项目 | 清肝活血方抑制LPCAT3/NAMPT轴介导的铁死亡改善酒精性肝病的机制研究 | 2026/01-2029/12 | 49 |
2 | 上海市人才工作局 | 上海市东方英才计划拔尖项目 | 2025/01-2028/12 | 20 |
3 | 上海市“科技创新行动计划”自然科学基金项目 | 二氢杨梅素通过抑制CDH11调控吲哚丙酸代谢改善肝纤维化的机制研究 | 2024/10-2027/09 | 20 |
4 | 上海中医药大学杏林百人计划 | 降脂颗粒有效成分改善NASH的机理研究 | 2021/01-2023/12 | 15 |
5 | 国家自然科学基金面上项目 | 清肝活血方通过LXR-LPCAT3信号通路抑制内质网应激改善酒精性肝病的机制研究 | 2019/01-2022/12 | 57 |
6 | 上海市人才发展基金 | LPCAT在NASH中的关键作用及降脂颗粒干预研究 | 2017/09-2020/08 | 20 |
第一/通讯作者代表性论文
(1) Ying Gao#, Hao Wu#, Yanqun Luo, Xiaoliang Deng, Junming Chen* and Tao Wu*. Exploring the Mechanism of Dihydromyricetin on Improving Hepatic fibrosis through the Integration of Metabolomics and Gut Microbiota. American Journal of Chinese Medicine2025,53(3):889-908（IF=5.5）
(2) Yanqun Luo#, Haiping Xue#, Ying Gao, Guang Ji*, Tao Wu*. Sphingosine kinase 2 in cancer: A review of its expression, function, and inhibitor development. International Journal of Biological Macromolecules. Volume 306, Part 1, May 2025, 141392（IF=8.5）
(3) Yanqun Luo#, Haiping Xue#, Hongyu Chen#, Ying Gao, Guang Ji*, Tao Wu *. Metabolomics Advances in Chronic atrophic gastritis Diagnosis and the Integration of Traditional Chinese Medicine.Saudi Pharmaceutical Journal. 2024（IF=3.4）32 (2024) 102213：1-9
(4) Ying Gao, Yanqun Luo, Guang Ji*, Tao Wu*. Functional and pathological roles of adenylyl cyclases in various diseases. International Journal of Biological Macromolecules281, 2024, 136198 SCI(IF=8.5)
(5) Yan-qun Luo*, Cai-yun Zhang*, Xia-zhen Nong, Ying Gao, Lei Wang#, Guang Ji#, Tao Wu#. Metabolomics in cirrhosis: Recent advances and opportunities. Clinica Chimica Acta 557(2024), 117886 SCI(IF=3.2)
(6) Ying Gao, Peilun Ding, Junmin Wang, Caiyun Zhang, Guang Ji*, Tao Wu*. Application of metabolomics in irritable bowel syndrome in recent 5 years. International Immunopharmacology 124 (2023) 110776 SCI(IF=5.7)
(7) Chenjia Zhou#, Ying Gao#, Peilun Ding, Tao Wu* and Guang Ji*. The role of CXCL family members in different diseases. Cell Death Discovery (2023) 9:212. (IF=7) （ESI高被引论文）
(8) Caiyun Zhang, Hongjiao Xiang, Junmin Wang, Gaoxuan Shao, Peilun Ding, Gao Ying, Hanchen Xu, Guang Ji*, Tao Wu*. Exploring the mechanism of Jianpi Huatan recipe in protecting hepatocellular carcinoma based on network pharmacology. Journal of Ethnopharmacology 4 June 2023,317, 116676 (IF=5.4)
(9) Qiaoli Sun, Yingjue Tang, Liang Dai, Zhipeng Tang, Wenjun Zhou, Tao Wu*, Guang Ji*. Serum Bile Acid Metabolites Predict the Therapeutic Effect of Mesalazine in Patients with Ulcerative Colitis. Journal of Proteome Research2023 10.1021/acs.jproteome.2c00820（IF=5.370）
(10) Junmin Wang, Yifei Lu, Caiyun Zhang, Shuxia Tian, Hongjiao Xiang, Peilun Ding, Junming Chen*, Guang Ji*, Tao Wu*. Qinggan Huoxue Recipe attenuates Alcoholic Liver Disease by suppressing PI3K/AKT signaling pathway based on network pharmacology. International Journal of Medical Sciences 2023; 20(3): 346-358（IF=3.642）
(11) Junmin Wang#, Qiaoli Sun#, Ying Gao#, Hongjiao Xiang, Caiyun Zhang, Peilun Ding, Tao Wu*, Guang Ji*. Metabolomics window into the diagnosis and treatment of inflammatory bowel disease in recent 5 years. International Immunopharmacology. Volume 113, Part B, 2022, 109472（IF=5.714）
(12) Guang Ji*, Guoxiang Xie, Tao Wu* and Yunping Qiu. Editorial: Nonalcoholic fatty liver disease: From pathogenesis to phytomedicine based on omics technology. Frontiers in Pharmacology 2022, 13: 1062979. (IF=5.988)
(13) Yifei Lu, Mingmei Shao, Caiyun Zhang, Hongjiao Xiang, Junmin Wang, Tao Wu* and Guang Ji*. Kaempferol attenuates nonalcoholic steatohepatitis by regulating serum and liver bile acid metabolism.Frontiers in Pharmacology 2022,13: 946360 (IF=5.988)
(14) Xiazhen Nong#, Caiyun Zhang#, Junmin Wang, Peilun Ding, Guang Ji*, Tao Wu*. The mechanism of branched-chain amino acid transferases in different diseases: research progress and future prospects. Frontiers in Oncology 2022,12: 988290 (IF=5.738)
(15) Mingmei Shao, Lu Yifei, Hongjiao Xiang, Junmin Wang, Guang Ji* and Tao Wu*. Application of Metabolomics in the Diagnosis of Non-alcoholic Fatty Liver Disease and the Treatment of Traditional Chinese Medicine.Frontiers in Pharmacology 2022,13: 971561. (IF=5.988)
(16) Ming-Mei Shao#, Hong-Jiao Xiang#, Hao Lu, Pei-Hao Yin, Guo-Wen Li, Yun-Man Wang, Lin Chen, Qing-Guang Chen, Cheng Zhao, Qun Lu, Tao Wu*, Guang Ji*. Potential metabolite markers of peripheral neuropathy in Chinese patients with type 2 diabetes. American Journal of Translational Research 2022;14(8):5420-5440 (IF=3.94)
(17) Hongyu Chen, Junmin Wang, Caiyun Zhang, Peilun Ding, Shuxia Tian, Junming Chen*, Guang Ji *, Tao Wu *. Sphingosine 1-phosphate receptor, a new therapeutic direction in different diseases. Biomedicine & Pharmacotherapy 2022; 153, 113341: 1-10 (IF=7.419)
(18) Tao Wu, Xiaojiao Zheng, Ming Yang, Aihua Zhao, Hongjiao Xiang, Tianlu Chen, Wei Jia*, Guang Ji*. Serum amino acid profiles predict the development of hepatocellular carcinoma in patients with chronic HBV infection. ACS omega 2022 Apr 25;7(18):15795-15808 (IF=3.512)
(19) Yifei Lu, Mingmei Shao, Hongjiao Xiang, Junmin Wang, Guang Ji *, Tao Wu*. Qinggan Huoxue Recipe alleviates chronic alcoholic liver injury by suppressing endoplasmic reticulum stress through LXR-LPCAT3. Frontiers in Pharmacology. 2022; 13:824185. (IF=5.988)
(20) Yirong Wang#, Junmin Wang#, Hongjiao Xiang, Peilun Ding, Tao Wu*, Guang Ji *. Recent update on application of dihydromyricetin in metabolic related diseases. Biomedicine & Pharmacotherapy 2022; 148, 112771: 1-9 (IF=7.419)
(21) Kaixu Yang#, Junmin Wang#, Hongjiao Xiang, Peilun Ding, Tao Wu*, Guang Ji*. LCAT- targeted therapies: Progress, failures and future. Biomedicine & Pharmacotherapy. 2022 Feb 1; 147: 112677, 1-13 (IF=7.419)
(22) Qinyi Wang#, Junmin Wang#, Hongjiao Xiang, Peilun Ding, Tao Wu*, Guang Ji*. The biochemical and clinical implications of phosphatase and tensin homolog deleted on chromosome ten in different cancers. Am J Cancer Res 2021; 11(12): 5833–5855. (IF=6.166)
(23) Junmin Wang, Hongjiao Xiang, Yifei Lu, Tao Wu* and Guang Ji*. New progress in drugs treatment of diabetic kidney disease. Biomedicine & Pharmacotherapy 141 (2021) 111918: 1-18 (IF=6.529)
(24) Hongjiao Xiang#, Mingmei Shao#, Yifei Lu, Junmin Wang, Tao Wu* and Guang Ji*. Kaempferol alleviates steatosis and inflammation during early non-alcoholic steatohepatitis associated with liver X receptor α-lysophosphatidylcholine acyltransferase 3 signaling pathway. Frontiers in Pharmacology 2021 Jun 28; 12: 690736 (IF=5.810)
(25) Junmin Wang, Hongjiao Xiang, Yifei Lu, Tao Wu* and Guang Ji*. The Role and Therapeutic Implication of CPTs in Fatty Acid Oxidation and Cancers Progression. Am J Cancer Res 2021 Jun 15;11(6):2477-2494 (IF=6.166)
(26) Tao Wu, Ming Yang, Hanchen Xu, Lei Wang, Huafeng Wei, Guang Ji*. Serum Bile Acid Profiles Improve Clinical Prediction of Nonalcoholic Fatty Liver in T2DM patients. Journal of Proteome Research2021, 20, 8, 3814–3825 (IF=4.466) (Supplementary封面论文）
(27) Hongjiao Xiang#, Shengjie Jin#, Fenglang Tan, Yifan Xu, Yifei Lu, Tao Wu*. Physiological functions and therapeutic applications of neutral sphingomyelinase and acid sphingomyelinase. Biomedicine &Pharmacotherapy139(2021)111610:1-13 (IF=6.529)
(28) Yifei Lu, Mingmei Shao, Hongjiao Xiang, Peiyong Zheng, Tao Wu* and Guang Ji*. Integrative transcriptomics and metabolomics explore the mechanism of kamepferol on improving NASH.Food & Function, 2020,11, 10058 - 10069 (IF=5.396)
(29) Mingmei Shao#, Hao Lu#, Ming Yang , Yang Liu, Peihao Yin, Guowen Li, Yunman Wang, Lin Chen, Qingguang Chen, Cheng Zhao, Qun Lu , Tao Wu*, and Guang Ji*. Serum and urine metabolomics reveal potential biomarkers of T2DM patients with nephropathy. Annals of Translational Medicine 2020;8(5):199 (IF=3.297)
(30) Jie Ren#, Yifei Lu#, Yanhong Qian, Bozhou Chen, Tao Wu* and Guang Ji*. Recent progress regarding kaempferol for the treatment of various diseases (Review). Exp Ther Med 18: 2759-2776, 2019 (IF=1.785)（ESI高被引论文）