陆冬 副研究员

陆冬 （Dong Lu）副研究员、硕士生导师

基本信息：

办公电话（Tel）：021-51322428

通讯地址（Address）：上海市浦东新区蔡伦路1200号科技创新楼3楼305室

邮箱（Email）：ludong@shutcm.edu.cn

研究方向（Direction）: 人工智能与药物设计在中药学中的应用

招生专业：

教育经历：

2007-2011  中国药科大学，制药工程专业，学士

2013-2018  中国科学院上海药物研究所，药物设计学专业，博士

任职经历：

2018-2021  上海中医药大学，交叉科学研究院，师资博士后

2021-2022  上海中医药大学，交叉科学研究院，助理研究员

2023-至今   上海中医药大学，交叉科学研究院，副研究员

科研概况：

目前研究工作聚焦于人工智能技术和中药研究的交叉融合，开发符合中药特色的新技术与新方法；计算机辅助药物靶标发现；基于靶点的中药活性分子的发现与设计等研究工作。基于生物、化学信息学和人工智能技术，开发了化合物半衰期预测模型，药物协同预测模型，以及组织特异性的药物靶标发现新工具FL-DTD等。近五年来，以（共同）第一或通讯作者在Briefings in Bioinformatics，Journal of Medicinal Chemistry，Phytomedicine，Advanced Science, Ultrasonics Sonochemistry等国际知名学术期刊发表研究论文。主持或作为骨干承担国家自然科学基金青年项目和面上项目，国家重点研发计划“中医药现代化”专项等。

 近五年承担的科研课题与经费：

1.  国家自然科学基金青年项目，2022/01-2024/12，30万，主持

2.  国家重点研发计划“中医药现代化”专项，2023/11-2026/10，550万，子任务负责人

3.  上海中医药大学预算内项目，2020/01-2021/12，6.6万，主持

代表性文章：

1. Shensuo Li^#, Lijun Zhang^#, Wen Zhang^#, Hongyu Chen, Mei Hong, Jianhua Xia, Weidong Zhang*, Xin Luan*, Guangyong Zheng*, Dong Lu*. Identifying traditional Chinese medicine combinations for breast cancer treatment based on transcriptional regulation and chemical structure. Chinese Medicine. 2025 Feb 14;20(1):23. (共同通讯，IF = 5.7)

2. Hongke Wei^#, Xiaomin Wang^#, Jiaqi Wang, Shijie Ren, Luis AJ Mur, Dong Lu*, Duo Cao*. Flavonoids from sour jujube leaves: Ultrasound-assisted extraction, UPLC-QQQ-MS/MS quantification, and ameliorative effect on DSS-induced ulcerative colitis in mice. Ultrasonics Sonochemistry. 2025 Mar;114:107279. (共同通讯，IF = 9.7)

3. Xinyu Han^#, Pu Wang^#, Le Zhang^#, Jingchuan Lin^#, Zi-Qiong Zhou, Dong Lu*, Ping Wang* and Yu Zhang*. Photoinduced Evolution of Flavanones via C-C Bond Formation for Potent COMT Inhibition. Journal of Natural Products. 2025 Jul 2. (共同通讯，IF = 3.6)

4. Liuyuan Xia^#, Xin Guo^#, Dong Lu^#, Yixin Jiang, Xiaohui Liang, Yiwen Shen, Jiayi Lin, Lijun Zhang, Hongzhuan Chen, Jinmei Jin*, Xin Luan*, Weidong Zhang*. S100A13-driven interaction between pancreatic adenocarcinoma cells and cancer-associated fibroblasts promotes tumor progression through calcium signaling. Cell Communication and Signaling. 2025 Jan 28;23(1):51. (共同一作，IF = 8.9)

5. Huiting Bian^#, Xiaohui Liang^#, Dong Lu^#, Jiayi Lin, Xinchen Lu, Jinmei Jin, Lijun Zhang, Ye Wu*, Hongzhuan Chen*, Weidong Zhang*, Xin Luan*. In Silico Discovery of Stapled Peptide Inhibitor Targeting the Nur77-PPAR Interaction and Its Anti-Breast-Cancer Efficacy. Advanced Science, 2024, 11(26): e2308435. (共同一作，IF = 14.1)

6. Hongyu Chen^#; Dong Lu^#; Ziyi Xiao; Shensuo Li; Wen Zhang; Xin Luan*; Weidong Zhang*; Guangyong Zheng*; Comprehensive applications of the artificial intelligence technology in new drug research and development. Health Information Science and Systems, 2024, 12(1):41. (共同一作，IF = 3.4)

7. Yi-Qing Deng^#, Min Gao^#, Dong Lu^#, Qiu-Ping Liu, Run-Jing Zhang, Ji Ye, Jing Zhao, Zhi-Hui Feng, Qi-Zhang Li*, Hong Zhang*. Compound-composed Chinese medicine of Huachansu triggers apoptosis of gastric cancer cells through increase of reactive oxygen species levels and suppression of proteasome activities. Phytomedicine. 2024 Jan;123:155169. (共同一作，IF = 8.3)

8. Dong Lu^#, Rongrong Pan^#, Wenxuan Wu^#, Yanyan Zhang, Shensuo Li, Hong Xu, Jialan Huang, Jianhua Xia, Qun Wang, Xin Luan, Chao Lv*, Weidong Zhang*, Guofeng Meng*. FL-DTD: an integrated pipeline to predict the drug interacting targets by feedback loop-based network analysis. Briefings in Bioinformatics. 2022 Jul 18;23(4):bbac263. (共同一作，IF = 9.5)

9. Pei An^#, Dong Lu^#, Lijun Zhang, Haiyue Lan, Hongxuan Yang, Guangbo Ge, Wei Liu, Weixing Shen, Xianting Ding, Dongxin Tang, Weidong Zhang, Xin Luan*, Haibo Cheng*, Hong Zhang*. Synergistic antitumor effects of compound-composed optimal formula from Aidi injection on hepatocellular carcinoma and colorectal cancer. Phytomedicine. 2022 Aug;103:154231. (共同一作，IF = 7.9)

10. Ye Wu^#, Dong Lu^#, Yixin Jiang, Jinmei Jin, Sanhong Liu, Lili Chen, Hong Zhang, Yudong Zhou, Hongzhuan Chen, Dale G. Nagle, Xin Luan*, Weidong Zhang*. Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma. Journal of Medicinal Chemistry. 2021 May 13;64(9):5802-5815. (封面文章，共同一作，IF = 8.0)