金强 高级实验师

发布者：交叉科学研究院-01发布时间：2022-06-03浏览次数：19183

个人简介

　　主要研究方向：1）药物代谢酶高通量分析方法的构建与应用及药物早期 ADME/T 相关研究。2）利用多组学技术分析肿瘤等代谢性疾病发生过程关键靶点，通过分子生物学和化学生物学技术开展靶点药物的筛选与药效评估。

招生专业

 

院系名称专业大类一级学科专业代码/专业名称学位类型招生类型
交叉科学研究院医学中药学100800/中药学学术学位硕士
交叉科学研究院医学中药学105600/中药学专业学位硕士


教育及任职经历

2008.09-2012.07  　郑州大学生命科学院　　　　　　　 生物工程，获学士学位

2013.09-2016.05  　中国科学院大连化学物理研究所        生物化工，获硕士学位

2016.06-2017.03  　郑州大学第一附属医院　　　　        技师

2017.04-2024.12　  上海中医药大学交叉科学研究院　　 实验师

2020.09-2023.12     上海中医药大学附属龙华医院            中药学，获博士学位

2025.01-至今     　  上海中医药大学交叉科学研究院         高级实验师

近五年获得的奖项

2021年 ，中药人源性代谢及其介导脏器毒性评价新技术与应用，科技进步。（排名第五）

近五年以第一负责人承担的科研课题与经费

序号

课题类型

项目时间

项目经费

（万元）

备注

1国家自然科学基金面上项目2025.01-2028.1248主持
2上海市自然科学基金面上项目2024.10-2027.920主持
3

国家自然科学基金青年科学基金

2019.01-2021.12

20

主持

代表性文章

     1.Jie Mu#, Si-Si Chen#, Shi-Qing Li, Qiang Jin*, Jin Geng*, Li-Wei Zou *, Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation.J Enzyme Inhib Med Chem. 40(1):2472817.(IF=5.4)

2. Yu Sun#, Guilin Wei#, Yongchen Wang, Chengwei Lü*, Qiang Jin*. A 1,3,4-thiadiazole based turn-on probe with large Stoke’s shift and ESIPT effect for fluorescent detection of H2S and its applications.Journal of Photochemistry and Photobiology A: Chemistry.2025, 116032.(IF = 4.7)

3.Qiang Jin#, Jing-Jing Wu#, Yue Wu, Hong-Xin Li, Moshe Finel, Dan-Dan Wang*, Guang-Bo Ge*, Optical substrates for drug-metabolizing enzymes: Recent advances and future perspectives. Acta Pharmaceutica Sinica B 2022;12(3):1068e1099. (IF= 14.6)

4.Qiang Jin#, Li-Lin Song#, Le-Le Ding, Jing Zhang, Dan-Dan Wang, Yun-Qing Song, Li-Wei Zou*, Guang-Bo Ge*, High-throughput optical assays for sensing serine hydrolases in living systems and their applications. TrAC Trends in Analytical Chemistry. 2022,152,116620. (IF= 12)

5. Qiang Jin#, Zan Li#, Meng-Jie Zhang#, Wen-Cai Liu, Li-Wei Zou, Hua Sui, Dan-Dan Wang*, Qing-Feng Tang*, Guang-Bo Ge*, Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate. Chemico-Biological Interactions.2022,368:110197 (IF= 5.4)

6. Haiguo Sun#, Mengyu Xi#, Qiang Jin#, Zhengdan Zhu, Yani Zhang, Guihua Jia, Guanghao Zhu, Mengru Sun, Hongwei Zhang, Xuelian Ren, Yong Zhang, Zhijian Xu, He Huang, Jingshan Shen, Bo Li*, Guangbo Ge*, Kaixian Chen, and Weiliang Zhu*. Chemo- and Site-Selective Lysine Modification of Peptides and Proteins under Native Conditions Using the Water-Soluble Zolinium. J Med Chem. 2022,65(17):11840-11853. (IF= 6.8)

7. Guilin Wei, Lijuan Xue, Yadi Zhu, Xingkai Qian, Liwei Zou, Qiang Jin*, Dandan Wang*, Guangbo Ge. Differences in susceptibility of HT‐29 and A549 cells to statin‐induced toxicity: An investigation using high content screening, Journal of Biochemical and Molecular Toxicology, 2021, e22699 (IF= 2.8)

8. Lijuan Xue, Xingkai Qian, Qiang Jin*, Yadi Zhu, Xiaoyu Wang, Dandan Wang*, Guangbo Ge, Ling Yang. Construction and application of a high-content analysis for identifying human carboxylesterase 2 inhibitors in living cell system, Analytical and Bioanalytical Chemistry, 2020, 412(11): 2645-2654. (IF= 3.8)

9. Qiang Jin, Hongying Ma, Lei Feng, Ping Wang, Rongjing He, Jing Ning, Ling Yang, Guangbo Ge*. Sensing cytochrome P450 1A1 activity by a resorufin-based isoform-specific fluorescent probe, Chinese Chemical Letters, 2020, 31(11): 2945-2949 (IF= 8.9)

10. Qiang Jin#, Lei Feng #, ShuiJun Zhang, DanDan Wang, FangJun Wang, Yi Zhang, Cui JingNan, WenZi Guo*, GuangBo Ge*, Ling Yang. Real-Time Tracking the Synthesis and Degradation of Albumin in Complex Biological Systems with a near-Infrared Fluorescent Probe. Anal. Chem. 2017, 89 (18), 9884-91. (IF= 6.7)

11. Qiang Jin#, Lei Feng#, DanDan Wang, JingJing Wu, Jie Hou, ZiRu Dai, Shi-Guo Sun, Jia-Yue Wang, Guang-Bo Ge*, Jing-Nan Cui*, Ling Yang*. A highly selective near-infrared fluorescent probe for carboxylesterase 2 and its bioimaging applications in living cells and animals. Biosensors and Bioelectronics,2016,83, 193-199. (IF=10.5)