陈莉莉 研究员

陈莉莉  研究员、硕士生导师

基本信息

办公电话：021-51322720

电子邮箱：llchen@shutcm.edu.cn

通讯地址：上海市浦东新区蔡伦路1200号创新楼9楼901室

招生专业

教育及任职经历

1994.9-1998.7       中国海洋大学               学士

1998.9-2001.7       中国海洋大学               硕士

2003.9-2006.7       中国科学院上海药物研究所       博士

2001.7-2009.8       中国科学院上海药物研究所       研究实习员、助理研究员、高级工程师

2009.9-2014.1        中国科学院上海药物研究所       副研究员

2014.1-2015.1         Emory University                                     访问学者

2015.1-2018.12       中国科学院上海药物研究所       副研究员

2019.1-至今    上海中医药大学交叉科学研究院     研究员

近五年以第一负责人承担的科研课题与经费

研究方向

中药抗病毒、抗感染活性成分研究及创新药物发现

代表性文章

1. Jiani Lu^#, Yingying He^#, Yaqi Li^#, Xixiang Chen, Hongtao Li, Xuwen Chen, Jianrong Xu, Hongzhuan Chen, Ying Wang, Xiao He*, Shunying Liu*, Lili Chen*. Exploring Bifunctional Molecules for Anti-SARS-CoV-2 and Anti-Inflammatory Activity through Structure-Based Virtual Screening, SAR investigation, and Biological Evaluation. Int J Biol Macromol. 2025, 287:138529. doi: 10.1016/j.ijbiomac.2024.138529. (最后通讯, IF=8.5)

2. Jiani Lu^#, Yan Tang^#, Hongtao Li, Xixiang Chen, Pengcheng Qin, Jianrong Xu, Weihua Li*, Lili Chen*. Identifying Exifone as a Dual-Target Agent Targeting Both SARS-CoV-2 3CL Protease and the ACE2/S-RBD Interaction Among Clinical Polyphenolic Compounds. Int J Mol Sci. 2025, 26(5):2243. doi: 10.3390/ijms26052243. (最后通讯, IF=4.9)

3. Jiani Lu^#, Yan Tang^#, Hongtao Li^#, Saisai Tian, Xixiang Chen, Xueyue Song, Pengcheng Qin, Jiangrong Xu, Haiyan Zhu, Liqiang Ni, Huarong Du*, Weidong Zhang*, Weihua Li*, Lili Chen*. Exploring anti-SARS-CoV-2 natural products: dual-viral target inhibition by delphinidin and the anti-coronaviral efficacy of deapio platycodin D. 2025, Nat Prod Bioprospect. 10.1007/s13659-025-00523-w. (最后通讯, IF=4.8)

4. Yuheng Song, Jiani Lu, Pengcheng Qin, Hongzhuan Chen, Lili Chen*. Interferon-I modulation and natural products: Unraveling mechanisms and therapeutic potential in severe COVID-19. Cytokine Growth Factor Rev. 2024, S1359-6101(24)00066-2. doi: 10.1016/j.cytogfr.2024.08.005. (最后通讯, IF=11.8)

5. Ruyu Wang^#, Xuwen Chen^#, Hongtao Li, Xixiang Chen, Donghui Sun, Danmei Yu, Jiani Lu, Yuanyuan Xie, Qian Zhang, Jianrong Xu, Weidong Zhang, Hongzhuan Chen, Shunying Liu*, Lili Chen*. Danshensu Inhibits SARS-CoV-2 by Targeting Its Main Protease as a Specific Covalent Inhibitor and Discovery of Bifunctional Compounds Eliciting Antiviral and Anti‐inflammatory Activity. Int J Biol Macromol. 2024, 257(Pt 2):128623 (最后通讯, IF=8.2)

6. Hongtao Li^#, Meng Sun^#, Fuzhi Lei^#, Jinfeng Liu, Xixiang Chen, Yaqi Li, Ying Wang, Jiani Lu, Danmei Yu, Yueqiu Gao, Jianrong Xu, Hongzhuan Chen, Man Li*, Zhigang Yi*, Xiao He*, Lili Chen*. Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3CL protease as a potential candidate against SARS-CoV-2 infection. Antiviral Res. 2024, 224:105841. (最后通讯, IF=7.6)

7. Ruyu Wang^#, Guanglei Zhai^#, Guanghao Zhu^#, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge^*,Hongzhuan Chen^*, Lili Chen^*. Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses. Bioorg Chem. 2023, 130: 106264. (最后通讯, IF=5.31)

8. Yusen Xiang^#, Guanglei Zhai^#, Mengge Wang, Xixiang Chen, Yaozong Li, Weidong Zhang, Guangbo Ge, Jianrong Xu^*, Hongzhuan Chen^*, Lili Chen^*. Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay. Int J Biol Macromol. 2023, 226:780-792. (最后通讯, IF=8.2)

9. Mengge Wang, Yusen Xiang, Ruyu Wang, Lijun Zhang, Hong Zhang, Hongzhuan Chen, Xin Luan*, Lili Chen*. Dihydrotanshinone I Inhibits the Proliferation and Growth of Oxaliplatin-Resistant Human HCT116 Colorectal Cancer Cells.Molecules. 2022, 27(22):7774. (最后通讯, IF=4.93)

10. Ruyu Wang^#, Qing Hu^#, Haonan Wang, Guanghao Zhu, Mengge Wang, Qian Zhang, Yishu Zhao, Chunyu Li, Yani Zhang, Guangbo Ge^*,Hongzhuan Chen^*, Lili Chen*, Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CL. Int J Biol Macromol. 2021, 183:182-192. (最后通讯, IF=8.0)

部分研究生获奖及毕业去向