王晓柠
研究员，主任医师，硕士研究生导师。上海中医药大学交叉科学研究院党委委员，中医方证基础研究中心主任。兼任上海市中西医结合学会器官纤维化专业委员会主任委员、中国中西医结合学会肝病专业委员会常务委员、世界中医药联合会亚健康专业委员会常务理事。
基本信息
办公电话：021-51322444
电子邮箱：wxn@shutcm.edu.cn
通讯地址：上海市浦东新区蔡伦路1200号120信箱
研究方向
慢性肝病的代谢表征、病理生物学机制
慢性肝病的中医证候生物学特征
招生专业
专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 | |
交叉科学研究院 | 医学 | 中医学 | 100506/中医内科学 | 学术学位 | 硕士 |
2019-1至今, 上海中医药大学交叉科学研究院, 研究员、主任医师
2016-4至2018-12, 上海中医药大学交叉科学研究院, 副研究员
2015-3至2020-7, 上海中医药大学中药学博士后流动站, 博士后
2013-8至2014-7, 美国夏威夷大学癌症中心, 高级访问学者
2013-1至2016-3, 上海中医药大学, 上海高校中医内科学E-研究院, 副研究员
2004-11至2012-12, 上海中医药大学, 上海高校中医内科学E-研究院, 助理研究员
2003-8至2004-10, 上海中医药大学附属曙光医院, 肝病研究所, 医师
2007-9至2011-7, 上海中医药大学, 中医内科学, 博士
2000-9至2003-7, 上海中医药大学, 中医内科学, 硕士
1995-9至2000-7, 上海中医药大学, 中医基础理论, 学士
序号 | 项目来源 | 项目名称 | 起止时间 | 经费(万元) |
1 | 上海市自然科学基金项目面上项目 | 胆汁酸代谢紊乱上调TGR5表达介导线粒体损伤在慢性胆汁淤积性肝病合并肌少症中的致病机制研究 | 2022.04-2025.03 | 20 |
2 | 国家自然科学基金面上项目 | 基于核受体FXR活化探讨茵陈蒿汤调控NAFLD胆汁淤积胆汁酸和脂肪代谢效应机制研究 | 2018.01-2021.12 | 53 |
3 | 国家自然科学基金面上项目 | 结合型胆汁酸-未结合胆红素比值升高在胆汁淤积中的致病作用及茵陈蒿汤干预机制研究 | 2016.01-2019.12 | 59 |
第一/通讯作者代表性论文
1. 杜曾，邱剑楠，郭真，王伊雯，戚莉，刘佳，王晓柠*. 不同剂量和疗程栀子苷调控慢性胆汁淤积的疗效/肝毒性效应机制[J]. 中华中医药杂志, 2022,37(7):4048-4053.
2. 邱剑楠, 戚莉, 杜曾, 王伊雯, 郭真, 刘馨烛, 刘佳, 刘平, 王晓柠*. 茵陈蒿汤调控脂肪代谢改善代谢相关脂肪性肝病的效应组分及其机制[J].中华中医药杂志, 2021,36(5):2894-2900.
3. Guoxiang Xie#, Runqiu Jiang#, Xiaoning Wang#, Ping Liu, Aihua Zhao, Yiran Wu, Fengjie Huang, Zhipeng Liu, Cynthia Rajani, Xiaojiao Zheng, Jiannan Qiu, Xiaoling Zhang, Suwen Zhao, Hua Bian, Xin Gao, Beicheng Sun, Wei Jia*. Conjugated secondary 12α-hydroxylated bile acids promote liver fibrogenesis[J]. EBioMedicine, 2021,66:103290.
4. Chao Sang#, Xiaoning Wang#, Kejun Zhou, Tao Sun, Hua Bian, Xin Gao, Yixing Wang, Hua Zhang, Wei Jia, Ping Liu*, Guoxiang Xie*, Tianlu Chen*. Bile Acid Profiles Are Distinct among Patients with Different Etiologies of Chronic Liver Disease[J]. Journal of Proteome Research, 2021,20(5):2340-2351.
5. Jiannan Qiu#, Jingyu Yan#, Wei Liu, Xinzhu Liu, Jingchao Lin, Zeng Du, Li Qi, Jia Liu, Guoxiang Xie*, Ping Liu*, Xiaoning Wang*. Metabolomics Analysis Delineates the Therapeutic Effects of Huangqi Decoction and Astragalosides on α-naphthylisothiocyanate (ANIT) -Induced Cholestasis in Rats[J]. Journal of Ethnopharmacology, 2021,268:113658.
6. Guoxiang Xie#, Xiaoning Wang#, Runmin Wei#, Jingye Wang#, Aihua Zhao, Tianlu Chen, Yixing Wang, Hua Zhang, Zhun Xiao, Xinzhu Liu, Youping Deng, Linda Wong, Cynthia Rajani, Sandi Kwee, Hua Bian, Xin Gao, Ping Liu*, Wei Jia*. Serum metabolite profiles are associated with the presence of advanced liver fibrosis in Chinese patients with chronic hepatitis B viral infection[J]. BMC Medicine,2020,18:144.
7. 贺晓立，王毅兴，王晓柠*，张华，慕永平，陈佳美，刘伟，蔡虹，刘平. 慢性乙型肝炎患者肝肾阴虚证和湿热蕴结证血清胆汁酸谱变化[J]. 中国中西医结合杂志,2020,40(5):528-534.
8. 刘馨烛，邱剑楠，戚莉，桑倪娜，罗盛波，刘佳，王晓柠*. 岩黄连对急性肝内胆汁淤积大鼠的干预作用及胆汁酸转运体表达的影响[J]. 中华中医药杂志,2019,34(4):1700-1704.
9. Guoxiang Xie#, Xiaoning Wang#, Runqiu Jiang#, Aihua Zhao, Jingyu Yan, Xiaojiao Zheng, Fengjie Huang, Xinzhu Liu, Jun Panee, Cynthia Rajani, Chun Yao, Herbert Yu, Weiping Jia, Beicheng Sun, Ping Liu*, Wei Jia*. Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure[J]. EBioMedicine,2018,37:294-306.
10. Jingyu Yan#, Guoxiang Xie#, Chungeng Liang#, Yiyang Hu, Aihua Zhao, Fengjie Huang, Ping Hu, Ping Liu*, Wei Jia*, Xiaoning Wang*. Herbal Medicine Yinchenhaotang Protects Against α-naphthylisothiocyanate-induced Cholestasis in Rats[J]. Scientific Reports, 2017,7:4211.
11. Guoxiang Xie#, Xiaoning Wang#, Aihua Zhao, Jingyu Yan, Wenlian Chen, Runqiu Jiang, Junfang Ji, Fengjie Huang, Yunjing Zhang, Sha Lei, Kun Ge, Xiaojiao Zheng, Cynthia Rajani, Rosanna A. Alegado, Jiajian Liu, Ping Liu, Jeremy Nicholson, Wei Jia*. Sex-dependent effects on gut microbiota regulate hepatic carcinogenic outcomes[J]. Scientific Reports, 2017,7:45232.
12. Guoxiang Xie#, Xiaoning Wang#, Fengjie Huang, Aihua Zhao, Wenlian Chen, Jingyu Yan, Yunjing Zhang, Sha Lei, Kun Ge, Xiaojiao Zheng, Jiajian Liu, Mingming Su, Ping Liu, Wei Jia*. Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis[J]. International Journal of Cancer, 2016,139(8):1764-1775.
13. Xiaoning Wang#, Guoxiang Xie#, Aihua Zhao, Xiaojiao Zheng, Fengjie Huang, Yixing Wang, Chun Yao, Wei Jia*, Ping Liu*. Serum Bile Acids are Associated with Pathological Progression of Hepatitis B-Induced Cirrhosis[J]. Journal of Proteome Research,2016,15(4):1126-1134.
14. Hongyang Zhang#, Xiaoning Wang#, Ping Hu*, Wenjun Zhou, Min Zhang, Jia Liu, Yuerong Wang, Ping Liu*, Guoan Luo. Serum Metabolomic Characterization of Liver Fibrosis in Rats and Anti-Fibrotic Effects of Yin-Chen-Hao-Tang[J]. Molecules,2016,21(1):126.
15. Wei Jia*, Tai-Ping Fan, Xiaoning Wang, Guoxiang Xie. The polypharmacokinetics of herbal medicines[J]. Science, 2015, 350(6262Suppl): S76-S79.
16. Guoxiang Xie#, Yixing Wang#, Xiaoning Wang#, Aihua Zhao, Tianlu Chen, Yan Ni, Linda Wong, Hua Zhang, Jue Zhang, Chang Liu, Ping Liu*, Wei Jia*. Profiling of serum bile acids in a healthy Chinese population using UPLC-MS/MS[J]. Journal of Proteome Research, 2015,14(2): 850-859.
17. Xiaoning Wang#, Guoxiang Xie#, Xiaoyan Wang, Mingmei Zhou, Huan Yu, Yan Lin, Guangli Du, Guoan Luo, Ping Liu*. Urinary metabolite profiling offers potential for differentiation of liver-kidney yin deficiency and dampness-heat internal smoldering syndromes in post-hepatitis B cirrhosis patients[J]. Evidence-Based Complementary and Alternative Medicine, 2015, 464969, doi:10.1155/2015/464969.
18. Xiaoning Wang, Xiaoyan Wang, Guoxiang Xie, Mingmei Zhou, Huan Yu, Yan Lin, Guangli Du, Guoan Luo, Wei Jia*, Ping Liu*. Urinary metabolite variation is associated with pathological progression of the post-hepatitis B cirrhosis patients[J]. Journal of Proteome Research, 2012,11(7): 3838-3847.
19. 王晓柠，刘平*. 肝纤维化研究发展的问题[J]. 传染病信息,2012,25(3):147-149, 173.
20. 王晓柠*，胡义扬. 系统生物学与中西医“病证结合”研究[J]. 中西医结合肝病杂志,2011,21(6):376-378.
21. 王晓柠，陶庆，冯琴，彭景华，刘平，胡义扬*. 一贯煎对CCl4诱导的肝纤维化大鼠肝组织胶原代谢的影响[J]. 中西医结合学报,2011,9(6):651-657.