邹立伟 研究员

邹立伟 

研究员，硕士生导师，杏林学者

上海中医药大学 交叉科学研究院 党委委员 

  办公电话：021-51323182

  电子信箱：chemzlw@163.com

  通讯地址：上海市浦东新区蔡伦路1200号科技创新楼A816 

  主要研究方向：药物代谢酶功能评价新方法开发与应用、中药功效物质分发现与成药性优化、中药-药物相互作用。先后在Acta Pharmaceutica Sinica B, Biosensors & Bioelectronics, TrAC Trends in Analytical Chemistry, ACS Sensors, Journal of Pharmaceutical Analysis, Organic Letters等国际知名期刊发表SCI论文80余篇，H因子28，引用>2500次。其中1篇为ESI热点论文，3篇为ESI高被引论文，1篇获2019 Acta Pharm Sin B. Outstanding Paper Award。已授权发明专利8项（含国际专利2项）。先后主持或参与“重大新药创制”国家重大专项、“中医药现代化研究”重点专项、国家自然科学基金、上海市自然科学基金等项目10项；作为项目负责人主持企业委托横向课题5项。参与编写《系统药代动力学》一部，英文专著《Pharmaceutical Biocatalysis》一部参。获世界中医药学会联合会“中医药国际贡献奖—科技进步”二等奖1项（排名第三）。Advanced Science, Biosensors & Bioelectronics, Journal of Medicinal Chemistry, Analytical Chemistry, Acta Pharmacologica Sinica, Bioorganic Chemistry等学术刊物审稿人。中国中药协会中药产品开发与培育专业委员会委员，中华中医药学会中药实验药理分会青年委员，药物代谢专业委员会第二届青年委员会委员，上海市药理学会药物代谢专业委员会委员，上海市药理学会中西医结合药理专业委员会委员。入选上海中医药大学“杏林学者”、国家中医药管理局“中医药国际化骨干人才培养”项目。

2024.01-至今，上海中医药大学，交叉科学研究院，研究员

2022.12-至今，上海交通大学, 化学化工学院（周永丰团队），访问学者

2019.12-2020.11，上海浦东科技和经济委员会，生物医药和新材料处，挂职

2018.01-2023.12，上海中医药大学，交叉科学研究院，副研究员

2017.03-2017.12，上海中医药大学，交叉科学研究院，助理研究员

2014.07-2017.02，中国科学院大连化学物理研究所，生物技术部，博士后

2010.09-2014.06，大连理工大学，制药科学与技术学院，有机化学，博士

  2008.07-2010.07，大连富乐马生物科技有限公司（Italy Flamma R＆D Center）,药物研发工程师

2005.09-2008.06，辽宁师范大学，化学化工学院，有机化学，硕士

2001.09-2005.07，辽宁师范大学，化学化工学院，应用化学，学士

1. Kun-Jie Bian#, Xin-Yi Zha#, Chang Dai, Jing Zhang, Yi-Nan Wang*, Xian-Ting Jiao*, Li-Wei Zou*, Rational design and evaluation of a novel Pepper aptamer-based biosensor for human carboxylesterase 2 and its application in the plasma detection of obese children, ACS Sensors, 2026, 11(3), 2545-2553. (IF =9.1) 

2. Xiao-Dong Li#, Meng-Ru Sun#, Jia-Qian Miao#, Cong Hu, Bei Zhao, Xia-Yan Chu, Ji-Cong Wu, Zhao Bin Guo, Chun-Yang Yu, Qiang Jin*, Li-Wei Zou*, Guang-Bo Ge*, Rational Engineering of a Large Stokes Shift Fluorogenic Sensor for Sensing Notum in Living Systems and Inhibitor Screening, Biosensors and Bioelectronics, 2026, 301, 118544. (IF = 10.7)

3. Ning Mao#, Shi-Qing Li#, Xiang-Lu Zhou, Cong Hu, Wen-Chao Wu, Hua Wei, Li-Wei Zou*, Ling Yang*, Rational design of a novel specific fluorescent substrate for monitoring hUGT1A4 activity and its application in identification of selective inhibitors, Journal of Pharmaceutical Analysis, 2026, 16(3), 101415.  (IF = 8.9)

4. Hong-hong Ma#, Xiao-Dong Li#, Xing-Kai Qian*, Li-Wei Zou*, Techniques for the determination of dipeptidyl peptidase IV and the screening of its inhibitors, Journal of Pharmaceutical Analysis, 2026, 16, 101499. (IF = 8.9)

5.  Chao-Hua Yan#, Gui-Lin Wei#, Zhuo-An Jin, Xiao-Dong Li, Liu-Yi Yang, Li-Wei Zou*, Ling Yang*, Elucidating the Substrate Specificity of Cytochrome P450 Enzymes: Insights into N- and S-Containing Small-Molecule Metabolis, Engineering, 2025, 54, 229-250. (IF = 11.6)

6. Chang-Sheng Lv#, Bin Wang#, Yan-Ze Zheng, Yu-Heng Wang, Jing Zhang, Jin-Guang Wang*, Li-Wei Zou*, Discovery of cardiovascular drugs as the effective inhibitors of human carboxylesterase, International Journal of Biological Macromolecules, 2025, 311, 143967. (IF = 8.5)

7. Wei-Ran Li#, Jie Mu#, An-Qi Wang, Qing-Liang Shu, Ming-Hang Li, Cheng-Wei Lü*, Li-Wei Zou*, Discovery of tri(indolyl)methanes as potent and selective inhibitors against humancarboxylesterase 2, International Journal of Biological Macromolecules, 2025, 307, 141868. (IF = 8.5)

8. Jie Mu#, Si-Si Chen#, Shi-Qing Li, Qing Jin*, Jin Geng*, Li-Wei Zou*, Discovery of lignans as the effective inhibitors of CES1A alleviate lipid droplets formation, Journal of Enzyme Inhibition and Medicinal Chemistry, 2025, 40(1), 2472817. (IF = 5.4)

9. Jing Zhang#, Kun-Jie Bian#, Yi-Jing Wang, Xing-Kai Qi, Jin Geng*, Hai-Dong Guo*, Li-Wei Zou*, NIR fluorescent substrate-driven discovery of prolyl endopeptidase natural inhibitors and its inhibition of alpha-synuclein aggregation and promotion of autophagy, Chemico-Biological Interactions, 2025, 421, 111733. (IF = 5.4)

10. Kun-Jie Bian, Xiaoze Bao*, Xiao-Dong Li, Damien Bonne, Li-Wei Zou*, Recent Progress on Prolyl Endopeptidase and Its ligands: Mechanisms of Recognition, Binding, Metabolism and Protein-Protein Interactions, Chemico-Biological Interactions, 2025, 111557. (IF = 5.4)

11.  Chao-Hua Yan#, Gui-Lin Wei#, Zhuo-An Jin#, Tian-Chi Lu, Xiao-dong Li, Ji-Cong Wu, Chun-Yang Yu, Li-Wei Zou*, Ling Yang*, Discovery and Evaluation of a Novel Selective FluorescentSubstrate for CYP3A4 Based on Sulfoxidation Characteristics, Chemical Communications, 2025, 61, 8871-8874. (IF = 4.2, Nature Index Journal)

12. Hao Li#, Kun-Jie Bian#, Xiu-Yang Wang, Xiao-Dong Li, Pei-Fang Song, Chun-Yang Yu, Guang-Bo Ge, Xing-Kai Qian*, Li-Wei Zou*, Yong-Feng Zhou, Ling Yang*, Activity-Based NIR Specific Fluorescent Probe Reveals the Abnormal Elevation of Prolyl Endopeptidase in Hippocampus during Alzheimer's Disease Progression, Sensors and Actuators B-Chemical, 2024, 417, 136071. (IF = 8.0)

13. Ci-Qin Li, Jin-Hui Shi*, Jie Mu, An-Qi Wang, Li-Wei Zou*, and Guang-Bo Ge*, Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects, Journal of Natural Products, 2023, 86, 1824-1831. (IF = 5.1)

14. Qiang Jin#, Li-Lin Song#, Le-Le Ding, Jing Zhang, Dan-Dan Wang, Yun-Qing Song, Li-Wei Zou*, Guang-Bo Ge*, High-throughput optical assays for sensing serine hydrolases in living systems and their applications, TrAC Trends in Analytical Chemistry, 2022, 152, 116620.  (IF = 14.9)

15. Dan-Dan Wang#, Xing-Kai Qian#, Hong-Xin Li, Gui-Hua Jia, Qiang Jin, Xin Luan, Ya-Di Zhu, Yi-Nan Wang, Jian Huang, Li-Wei Zou*, Guang-Bo Ge*, Ling Yang*, Sensing and imaging of exosomal CD26 secreted from cancer cells and 3D colorectal tumor model using a novel near-infrared fluorogenic probe, Materials Science & Engineering C, 2021, 130, 112472. (IF = 7.3)

2019级硕士：张  静（已毕业，上海市优秀毕业生，第一或共一作者发表论文6篇）

2020级硕士：王安琪（已毕业，第一或共一者发发表论文3篇）

2021级硕士：李赐琴（已毕业，上海中医药大学优秀毕业生，研究生国家奖学金，第一或共一作者发表论文3篇）

2022级硕士：母  婕（已毕业，第一或共一作者发表论文4篇）

2023级硕士：卞坤杰（在读，上海市优秀毕业生，研究生国家奖学金，第一或共一作者发表论文4篇）

2024级硕士：梁冰洁（在读）

2024级硕士：代  畅（在读）

2025级硕士：段金凤（在读）

2025级硕士：耿磊欣（在读）