邹立伟
研究员，硕士生导师，杏林学者
基本信息 |
办公电话：021-51323182
电子信箱：chemzlw@163.com
通讯地址：上海市浦东新区蔡伦路1200号科技创新楼A816
个人简介 |
主要研究方向：药物代谢酶检测新方法开发与应用、中药活性成分发现与成药性优化、中药-药物相互作用。先后在TrAC Trends in Analytical Chemistry, Biosensors & Bioelectronics, Acta Pharmaceutica Sinica B, ACS Sensors, Materials Science & Engineering C, Organic. Letters, European Journal of Medicinal Chemistry等国际知名期刊发表SCI论文70余篇，H因子24，引用>2000次。其中1篇为ESI热点论文，3篇为ESI高被引论文，1篇获2019 Acta Pharm Sin B. Outstanding Paper Award。已授权发明专利8项（含国际专利2项）。先后主持或参与“重大新药创制”国家重大专项、“中医药现代化研究”重点专项、国家自然科学基金、上海市自然科学基金等项目10项；作为项目负责人主持企业委托横向课题5项。参与编写《系统药代动力学》一部，英文专著《Pharmaceutical Biocatalysis》一部参。获世界中医药学会联合会“中医药国际贡献奖—科技进步”二等奖1项（排名第三）。Biosensors & Bioelectronics, Journal of Medicinal Chemistry, Analytical Chemistry, Acta Pharmacologica Sinica, Bioorganic Chemistry等学术刊物审稿人。中国中药协会中药产品开发与培育专业委员会委员，中华中医药学会中药实验药理分会青年委员、药物代谢专业委员会第二届青年委员会委员，上海药理学会药物代谢专业委员会委员。入选上海中医药大学“杏林学者”、国家中医药管理局“中医药国际化骨干人才培养”项目。
招生专业 |
院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
交叉科学研究院 | 医学 | 中药学 | 100800/中药学 | 学术学位 | 硕士 |
交叉科学研究院 | 医学 | 中药学 | 105600/中药学 | 专业学位 | 硕士 |
教育及任职经历 |
2024.01-至今，上海中医药大学，交叉科学研究院，研究员
2022.12-至今，上海交通大学, 化学化工学院（周永丰团队），访问学者
2019.12-2020.11，上海浦东科技和经济委员会，生物医药和新材料处，挂职
2018.01-2023.12，上海中医药大学，交叉科学研究院，副研究员
2017.03-2017.12，上海中医药大学，交叉科学研究院，助理研究员
2014.07-2017.02，中国科学院大连化学物理研究所，生物技术部，博士后
2010.09-2014.06，大连理工大学，制药科学与技术学院，有机化学，博士
2008.07-2010.07，大连富乐马生物科技有限公司（Italy Flamma R＆D Center）,药物研发工程师
2005.09-2008.06，辽宁师范大学，化学化工学院，有机化学，硕士
2001.09-2005.07，辽宁师范大学，化学化工学院，应用化学，学士
近五年以第一负责人承担的科研课题与经费 |
序号 | 课题类型 | 课题名称 | 项目时间 | 项目经费 （万元） | 备注 |
1 | 国家重大专项“重大新药创制”子课题 | -- | 2018.01-2020.12 | 113.04 | 主持 |
2 | 国家科技部重点研发计划“中医药现代化研究” | -- | 2018.01-2021.12 | 99/1898 | 任务负责人 |
3 | 国家自然科学青年基金 | -- | 2017.01-2019.12 | 20 | 主持 |
4 | 上海中医药大学第五批“杏林中青年人才”项目 | -- | 2021.01-2023.12 | 15 | 主持 |
5 | 上海市自然科学基金面上项目 | -- | 2023.04-2026.03 | 20 | 主持 |
代表性论文 |
1. Hao Li#, Kun-Jie Bian#, Xiu-Yang Wang, Xiao-Dong Li, Pei-Fang Song, Chun-Yang Yu, Guang-Bo Ge, Xing-Kai Qian*, Li-Wei Zou*, Yong-Feng Zhou, Ling Yang*, Activity-Based NIR Specific Fluorescent Probe Reveals the Abnormal Elevation of Prolyl Endopeptidase in Hippocampus during Alzheimer's Disease Progression, Sensors and Actuators B-Chemical, 2024, 417, 136071. (IF = 8.4)
2. Yu Sun#, Jie Mu#, Yongchen Wang, Chengwei Lü*, Li-Wei Zou*, Rational synthesis of 1,3,4-thiadiazole based ESIPT-ffuorescent probe for detection of Cu2+ and H2S in herbs, wine and fruits, Analytica Chimica Acta, 2024, 1297, 342379. (IF = 6.1)
3. Hao Li#, Xiao-Dong Li#, Chao-Hua Yan, Zhen-Hua Ni, Mu-Han Lü*, Li-Wei Zou*, Ling Yang*, Rational design of a near-infrared fluorescent probe for monitoring butyrylcholinesterase activity and its application in development of inhibitors, Frontiers in Bioengineering and Biotechnology, 2024, 12, 1387146. (IF = 5.7)
4. Dan-Dan Wang*,#, Zhen-Zhen Wang#, Wen-Cai Liu#, Xing-Kai Qian*, Ya-Di Zhu, Tie-Gang Wang, Shu-Mei Pan, Li-Wei Zou*, Pyrazolone compounds could inhibit CES1 and ameliorates fat accumulation during adipocyte differentiation, Bioorganic Chemistry, 2024, 150, 107536. (IF = 5.1)
5. Ci-Qin Li, Jin-Hui Shi*, Jie Mu, An-Qi Wang, Li-Wei Zou*, and Guang-Bo Ge*, Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects, Journal of Natural Products, 2023, 86, 1824-1831. (IF = 5.1)
6. Qiang Jin#, Li-Lin Song#, Le-Le Ding, Jing Zhang, Dan-Dan Wang, Yun-Qing Song, Li-Wei Zou*, Guang-Bo Ge*, High-throughput optical assays for sensing serine hydrolases in living systems and their applications, TrAC Trends in Analytical Chemistry, 2022, 152, 116620. (IF = 14.9)
7. Jing Zhang#, Qiu-Sha Pan#, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun**, Li-Wei Zou*, Ling Yang, Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 371, 629-640. (IF = 5.2)
8. Pei-Fang Song#, Qui-Sha Pan#, Zhao-Hui Sun, Li-Wei Zou*, Ling Yang*, Fibroblast activation protein alpha: Comprehensive detection methods for drug target and tumor marker, Chemico-Biological Interactions, 2022, 354, 109830. (IF = 5.8)
9. Dan-Dan Wang#, Xing-Kai Qian#, Hong-Xin Li, Gui-Hua Jia, Qiang Jin, Xin Luan, Ya-Di Zhu, Yi-Nan Wang, Jian Huang, Li-Wei Zou*, Guang-Bo Ge*, Ling Yang*, Sensing and imaging of exosomal CD26 secreted from cancer cells and 3D colorectal tumor model using a novel near-infrared fluorogenic probe, Materials Science & Engineering C, 2021, 130, 112472. (IF = 7.3)
10. Yun-Qing Song#, Qiang Jin#, Dan-Dan Wang, Li-Wei Zou*, Guang-Bo Ge*, Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism. Chemico-Biological Interactions, 2021, 345, 109566. (IF = 5.2)
11. Dan-Dan Wang#, Li-Wei Zou#, Qiang Jin, Xiao-Qing Guan, Yang Yu, Ya-Di Zhu, Jian Huang, Peng Gao, Ping Wang, Guang-Bo Ge*, Ling Yang*, A bioluminescent sensor reveals that carboxylesterase 1A is a novel endoplasmic reticulum-derived serologic indicator for hepatocyte injury, ACS Sensors, 2020, 5, 1987-1995. (IF = 8.9)
12. Yi-Shu Zhao#, Xing-Kai Qian#, Xiao-Qing Guan, Pei-Fang Song, Yun-Qing Song, Rong-Jing He, Meng-Ru Sun, Xiu-Yang Wang, Li-Wei Zou*, Guang-Bo Ge*. Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2, Bioorganic Chemistry, 2020,105, 104367. (IF = 5.3)
13. Dan-Dan Wang#, Li-Wei Zou#, Qiang Jin, Jie Hou, Guang-Bo Ge*, Ling Yang, Human carboxylesterases: a comprehensive review, Acta Pharmaceutica Sinica B, 2018, 8, 699-712. (IF = 14.5, ESI高被引论文)
14. Xiao-Ze Bao, Shi-Qiang Wei, Xing-Kai Qian, Jing-Ping Qu, Bao-Min Wang*, Li-Wei Zou*, Guang-Bo Ge, Asymmetric Construction of a Multi-pharmacophore-containing dispirotriheterocyclic scaffold and identification of a human carboxylesterase 1 inhibitor, Organic Letters, 2018, 20, 3394-3398. (IF = 6.6)
15. Li-Wei Zou#, Ping Wang#, Xing-Kai Qian, Lei Feng, Yang Yu, Dan-Dan Wang, Qiang Jin, Jie Hou, Zhi-Hong Liu, Guang-Bo Ge*, Ling Yang*, A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems, Biosensors & Bioelectronics, 2017, 90, 283-289. (IF = 12.6)
培养研究生情况 |
1.张静，2019级硕士
Ø 获得荣誉：
2022，上海市优秀毕业生
2021，上海中医药大学优秀团员
2021，上海中医药大学优秀学生
2021，上海中医药大学一等奖学金
2021，上海“中医药的传承与创新”研究生论坛二等奖
2021，第七届上海大学生创新创业成果展“优秀项目报告奖”
2021，第六届“浦江 DMPK 论坛”优秀奖
Ø 发表论文：
Jing Zhang#, Ya-Di Zhu#, Ci-Qin Li, Yi-Ming Fan, Hong Huo, Cheng-Gong Sun, Jing Zhou, Lei Sun*, Xing-Kai Qian*, Li-Wei Zou*, A sensitive fluorescence assay of serum dipeptidyl peptidase IV activity to predict the suitability of its inhibitors in patients with type 2 diabetes mellitus, Journal of Pharmaceutical and Biomedical Analysis, 2024, 249, 116382.
Hong-Hong Ma#, Jing Zhang#, Ci-Qin Li, Li-Wei Zou*, Discovery of anthraquinones as DPP-IV inhibitors: structure-activity relationships and inhibitory mechanism, Fitoterapia, 2023, 168, 105549.
Jing Zhang#, Qiu-Sha Pan#, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun**, Li-Wei Zou*, Ling Yang, Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 371, 629-640.
Xing-Kai Qian#, Jing Zhang#, Xiao-Dong Li, Pei-Fang Song, Li-Wei Zou*, Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry, 2022, 29, 2167-2188.
Jing Zhang#, Ci-Qin Li#, Li-Juan Tian, Xing-Kai Qian, An-Qi Wang, Shi-Yang Li, Cong-Cong Zhang*, Li-Wei Zou*, Study on the Inhibition of Six Kinds of Hypoglycemic Chinese Patent Medicines on Dipeptidyl Peptidase-IV, Integrative Food, Nutrition and Metabolism, 2022, 9, 1-8.
Jing Zhang, Xing-Kai Qian, Pei-Fang Song, Xiao-Dong Li, An-Qi Wang, Hong Huo, Jing-Chun Yao, Gui-Min Zhang* and Li-Wei Zou*, A high-throughput screening assay for dipeptidyl peptidase-IV inhibitors using human plasma, Analytical Methods, 2021, 13, 2671-2678.
Xing-Kai Qian#, Jing Zhang#, Pei-Fang Song, Yi-Su Zhao, Hong-Ying Ma, Qiang Jin, Dan-Dan Wang, Xiao-Qing Guan, Shi-Yang Li, XiaoZe Bao*, Li-Wei Zou*, Discovery of Pyrazolones as Novel Carboxylesterase 2 Inhibitors that Potently Inhibit the Adipogenesis in Cells, Bioorganic & Medicinal Chemistry, 2021, 40, 116187.
Jing Zhang#, Yang Yang#, Xing-Kai Qian, Pei-Fang Song, Yi-Shu Zhao, Xiao-Qing Guan*, Li-Wei Zou*, Xiaoze Bao*, and Hong Wang. Design Synthesis and Structure Activity Relationship Study of Pyrazolones as Potent Inhibitors against Pancreatic Lipase, ChemMedChem, 2021, 16(10), 1600-1604.
Ø 专利申请：
邹立伟，张静，宋培放，李小东，王安琪，李嫣然，虎杖水提物及其成分在制备防治糖尿病的药物中的应用，专利申请号：20211045618852.
邹立伟，张静，李小东，宋培放，王安琪，王乐天，黄连水提物及其成分在制备防治糖尿病的药物中的应用，专利申请号：20211045318703.
2.李赐琴，2021级硕士
Ø 获得荣誉：
2024，上海中医药大学校优秀毕业生
2024，上海中医药大学优秀团员
2023，研究生国家奖学金
2023，上海中医药大学一等奖学金
2022，上海中医药大学二等奖学金
Ø 发表论文：
Ci-Qin Li#, Zhao-Hui Sun#, Kun-Jie Bian, Qing-Guang Zhang*, Li-Wei Zou*, Novel hemicyanine dyes with a large Stokes shift and strong fuorescence: mitochondrial-targeted imaging, Chemical Papers, 2024, 78, 1687-1697.
Ci-Qin Li, Jin-Hui Shi*, Jie Mu, An-Qi Wang, Li-Wei Zou*, and Guang-Bo Ge*, Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects, Journal of Natural Products, 2023, 86, 1824-1831.
Jing Zhang#, Ci-Qin Li#, Li-Juan Tian, Xing-Kai Qian, An-Qi Wang, Shi-Yang Li, Cong-Cong Zhang*, Li-Wei Zou*, Study on the Inhibition of Six Kinds of Hypoglycemic Chinese Patent Medicines on Dipeptidyl Peptidase-IV, Integrative Food, Nutrition and Metabolism, 2022, 9, 1-8.
Jianing Zhao, Ci-qin Li, Sihan Wei, Chengwei Lü*, Li-Wei Zou*, A multifunctional fluorescent probe based on Schiff base with AIE and ESIPT characteristics for effective detections of Pb2+, Ag+ and Fe3+, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2023, 300, 122904.