基本信息
办公电话：021-51322433
通讯地址：上海市浦东新区蔡伦路1200号中医药科技创新中心B304
研究方向：中药抗肿瘤药理与肿瘤发病机制
个人简介
主要从事中药抗肿瘤药理及肿瘤发病分子机制研究。发现在结直肠癌发生和发展过程中起到重要作用的NFκB、STAT3和Wnt信号通路组成性激活的新机制（Cell Death and Disease, 2023; STTT, 2020; JMCB, 2018; Gastroenterology, 2014），发现转录后调控蛋白PUMILIO为结直肠癌治疗干预的新靶标（Nature Communications, 2022），发现一批在肿瘤治疗中极具应用潜力的小分子化合物（Cell Reports Medicine, 2024; APSB, 2024; Cell Chemical Biology, 2023; Journal of Medicinal Chemistry, 2023; Molecular Therapy-Oncolytics, 2022; Theranostics, 2021）。目前研究工作主要从免疫杀伤等方面寻找抗肿瘤中药小分子化合物，并阐释其抗肿瘤的分子机制。
在Gastroenterology、Nature Communications、Intensive Care Medicine、Cell Reports Medicine、PNAS、STTT、APSB、Clinical and Translational Medicine、Journal of Medicinal Chemistry、Cell Chemical Biology等期刊上发表SCI研究论文50余篇（总IF>590，平均IF>10）。先后主持国家自然科学基金等课题和人才项目10余项，申请国内外专利15项，授权10项。担任Developmental Cell、Cell Reports Medicine、STTT、APSB等杂志审稿专家、国家自然科学基金委评审专家、教育部学位办评审专家、《生命的化学》编委会委员、中国生化学会生物技术专业委员会常务委员、中国科协科技人才奖项特聘专家。先后荣获上海市东方英才拔尖人才、上海中医药大学珍宝岛讲座教授、赛诺菲-中国科学院上海生命科学研究院优秀青年科学家、上海中医药大学第四届“我心目中的好老师”等荣誉称号。
招生专业
| 院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
| 交叉科学研究院 | 医学 | 中药学 | 100800/中药学 | 学术学位 | 博士/硕士 |
| 交叉科学研究院 | 医学 | 中药学 | 105600/中药学 | 专业学位 | 硕士 |
教育及任职经历
1997.09-2001.07 河南农业大学 学士
2001.09-2004.06 中国农业科学院 硕士
2004.09-2008.01 中国农业科学院 博士
2008.02-2015.02 中国科学院上海生命科学研究院 助理研究员、博士后、副研究员
2015.03-2020.06 上海科技大学免疫化学研究所 副研究员
2020.07-至今 上海中医药大学交叉科学研究院 研究员、博士生导师
近五年以第一负责人承担的科研课题与经费
| 序号 | 课题类型 | 项目时间 | 项目经费 （万元） | 备注 |
1 | 国家自然科学基金面上项目 | 2024.01-2027.12 | 49 | 主持 |
| 2 | 上海市东方英才拔尖项目 | 2024.01-2026.12 | 40 | 主持 |
| 3 | 校企合作项目 | 2022.09-2025.09 | 300 | 主持 |
| 4 | 上海市地方高水平大学建设引进人才科研经费 | 2020.07-2023.07 | 150 | 主持 |
| 5 | 国家自然科学基金面上项目 | 2018.01-2021.12 | 60 | 主持 |
代表性文章
1. Qun Wang#, Jinxin Wang#, Dianping Yu#, Qing Zhang#, Hongmei Hu, Mengting Xu, Hongwei Zhang, Saisai Tian, Guangyong Zheng, Dong Lu, Jiajia Hu, Mengmeng Guo, Minchen Cai, Xiangxin Geng, Yanyan Zhang, Jianhua Xia, Xin Zhang, Ang Li, Sanhong Liu*, Weidong Zhang*. Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell Reports Medicine. 2024. 5(2):101357. IF=14.3
2. Yanyan Zhang#, Yun Huang#, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang*, Sanhong Liu*, Weidong Zhang*. Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22. Acta Pharm Sin B. 2024. in press. IF=14.7
3. Jianhua Xia#, Mengting Xu#, Hongmei Hu, Qing Zhang,Dianping Yu, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Yanyan Zhang, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang*, Sanhong Liu*, Weidong Zhang*. 5,7,4'-trimethoxyflavone triggers cancer cell PD-L1 ubiquitin-proteasome degradation and facilitates antitumor immunity by targeting HRD1. MedComm. 2024. in press. IF=10.7
4. Zhou H#, Shen Y#, Zheng G#, Zhang B#, Wang A, Zhang J, Hu H, Lin J, Liu S*, Luan X*, Zhang W*. Integrating single-cell and spatial analysis reveals MUC1-mediated cellular crosstalk in mucinous colorectal adenocarcinoma. Clinical and Translational Medicine. 2024. 14(5):e1701. IF=10.6
5. Wendan Zhang#, Honghong Jiang#, Pengli Huang#, Gaosong Wu, Qun Wang, Xin Luan, Hongwei Zhang, Dianping Yu, Hongru Wang, Dong Lu, Haonan Wang*, Huazhang An*, Sanhong Liu*, Weidong Zhang*. Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy. Clinical and Translational Medicine. 2023. 13: e1449. IF=10.6
6. Wendan Zhang#, Honghong Jiang#, Gaosong Wu#, Pengli Huang#, Haonan Wang*, Huazhang An*, Sanhong Liu*, Weidong Zhang*. The pathogenesis and potential therapeutic targets in sepsis. MedComm. 2023. 4: e418. IF=10.7
7. Chao Lv#, Yun Huang#, Qun Wang#, Chengji Wang#, Hongmei Hu, Hongwei Zhang, Dong Lu, Honghong Jiang, Ruling Shen, Weidong Zhang*, Sanhong Liu*. Ainsliadimer A induces ROS-mediated apoptosis in colorectal cancer cells via directly targeting peroxiredoxin 1 and 2. Cell Chemical Biology, 2023. 30: 295-307. 封面文章，IF=9.039
8. Panpan Fu#, Qun Wang#, Qing Zhang#, Yang Jin, Jin Liu, Kaixian Chen, Yuewei Guo*, Sanhong Liu*, Xuwen Li*. Bioactivity-Driven Synthesis of Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting PD-L1. Journal of Medicinal Chemistry, 2023. doi: 10.1021/acs.jmedchem.2c01702. IF=8.039
9. Ye D#, Liu H#, Zhao G#, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S*, Liu S*, Zhang X*. LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis. Cell Death and Disease. 2023. 14(2):165. IF=9.685
10. Yuanyuan Gong#, Zukai Liu#, Yihang Yuan#, Zhenzhen Yang#, Jiawei Zhang, Qin Lu, Wei Wang, Chao Fang*, Haifan Lin*, Sanhong Liu*. PUMILIO proteins promote colorectal cancer growth via suppressing p21. Nature Communications. 2022. 13(1):1627. IF=17.694
11. Yun Zhang, Shuaijun Li, Peisheng Jin, Ting Shang, Ruizhu Sun, Laiya Lu, Kaijin Guo, Jiping Liu, Yuanjuan Tong, Junbang Wang, Sanhong Liu, Chen Wang, Yubing Kang, Wenmin Zhu, Qian Wang, Xiaoren Zhang, Feng Yin, Yi Sun*, Lei Cui*. Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis, Nature Communications. 2022. 4;13(1):2447. IF=17.694
12. Zhang H#, Hu Y#, Liu D#, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B, Zhang X*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death and Differentiation. 2022. 10.1038/s41418-021-00921-w. IF=12.067
13. Jin J#, Wu Y#, Zhao Z#, Wu Y, Zhou YD, Liu S, Sun Q, Yang G, Lin J, Nagle DG, Qin J, Zhang Z, Chen HZ, Zhang W, Sun S, Luan X*. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. JCI Insight. 2022. 7(22):e160606. IF=9.484
14. Huang R#, Zhang LJ#, Jin JM#, Zhou YD, Zhang HW, Lv C, Lu D, Wu Y, Zhang H, Liu SH, Chen HZ, Luan X*, Zhang WD*. Bruceine D inhibits HIF-1a-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction. Acta Pharm Sin B. 2021. 11(11):3481-3492. IF=14.903
15. Hu Y#, Zhang H#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death and Differentiation. 2021. 10.1038/s41418-021-00908-7. IF=12.067
16. Jiang Y#, Li F#, Gao B#, Ma M, Chen M, Wu Y, Zhang W, Sun Y*, Liu S*, Shen H*. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. Theranostics. 2021. 11: 3868-3881. 封面文章，IF=11.6
17. Zang X#, Wang Q#, Zhou H#, Liu S*, Xue X*. Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study. Intensive Care Medicine. 2020. 46: 1927-1929. IF=41.787
18. Xue XY#, Liu YX#, Wang C#, Gu XJ#, Xue ZQ, Zang XL, Ma XD, Deng H, Liu R*, Pan L*, Liu SH*. Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma. Signal Transduction and Targeted Therapy. 2020. 5: 77. IF=38.104
19. Chen X#, Wang C#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin EY, Chen S, Liu Y, Wang M, Liu S*, Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy. 2020. 5: 52. 封面文章，IF=38.104
20. Shi S, Yang ZZ, Liu S, Yang F, Lin H*. PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. Proc Natl Acad Sci U S A. 2020. 117: 22390-22401. IF=12.779
21. Jiang Y#, Li C#, Wu Q#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F*, Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nature Communications. 2019.10: 2935. IF=17.694
22. Tao Y#, Liu Z#, Hou Y, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M*, Zhang X*. Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. Oncogene. 2018. 37: 5887-5900. IF=8.756
23. Liu S#*, Wang Z#, Liu Z#, Shi S, Zhang Z, Zhang J, Lin H*. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer. Journal of Molecular Cell Biology. 2018. 10: 302-315. 封面文章，IF=8.185
24. Ge QL#, Liu SH#, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR*, Teng YC*. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis. Cell Death and Disease. 2016. 7: e2402. IF=9.685
25. Wang Z, Liu N, Shi S, Liu S*, Lin H*. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. Journal of Biological Chemistry. 2016. 291: 10646-10658. F1000推荐论文，IF=5.486
26. Liu S#, Sun X#, Wang M#, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 2014. 147: 847-859.e811. IF=33.883