基本信息
办公电话：021-51322433
通讯地址：上海市浦东新区蔡伦路1200号中医药科技创新中心B304
研究方向：中药抗肿瘤药理与肿瘤发病机制
个人简介
主要从事中药抗肿瘤药理与肿瘤发病分子机制研究，围绕“扶正祛邪”理论，发现一批极具应用潜力的中药抗肿瘤小分子化合物，并系统阐释了NFκB、STAT3和Wnt信号通路在结直肠癌发生发展中的持续性激活机制。目前主要从免疫调节等方面寻找抗肿瘤中药小分子药物，并解析其抗肿瘤的分子机制。
在Gastroenterology、Nature Communications、JACS、Cell Reports Medicine、STTT、Advanced Science、Intensive Care Medicine、APSB等杂志发表SCI论文60余篇，29篇IF>10，7篇封面文章，总IF>700。先后主持和参与国家级、省部级课题和人才项目20余项，申请国内外专利15项，授权12项。荣获上海市东方英才拔尖人才、上海市浦东新区明珠计划领军人才、上海中医药大学珍宝岛讲座教授、赛诺菲-中国科学院上海生命科学研究院优秀青年科学家、上海中医药大学第四届“我心目中的好老师”等荣誉称号。担任中国工程院特聘评审专家、国家自然科学基金委评审专家、教育部学位办评审专家、中国科协科技人才奖项特聘专家、《生命的化学》编委会委员、中国生化学会生物技术专业委员会常务委员以及Developmental Cell、Cell Reports Medicine、Advanced Science、STTT、APSB、Cell Reports等杂志审稿专家。
招生专业
| 院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
| 交叉科学研究院 | 医学 | 中药学 | 100800/中药学 | 学术学位 | 博士/硕士 |
| 交叉科学研究院 | 医学 | 中药学 | 105600/中药学 | 专业学位 | 硕士 |
教育及任职经历
1997.09-2001.07 河南农业大学 学士
2001.09-2004.06 中国农业科学院 硕士
2004.09-2008.01 中国农业科学院 博士
2008.02-2015.02 中国科学院上海生命科学研究院 助理研究员、博士后、副研究员
2015.03-2020.06 上海科技大学免疫化学研究所 副研究员
2020.07-至今 上海中医药大学交叉科学研究院 研究员、博士生导师
近五年以第一负责人承担的科研课题与经费
代表性文章
1. Xiaoyu Tao#, Hongru Wang#, Qun Wang#, Chengji Wang#, Chang-Wei Shao, Yang Jin, Dianping Yu, Hongmei Hu, Qing Zhang, Mengting Xu, Xiangxin Geng, Hanchi Xu, Linyang Li, Ruling Shen, Yue-Wei Guo*, Xu-Wen Li*, Sanhong Liu*, Weidong Zhang*. Marine Natural Product Chagosendine C Induces Cuproptosis in Colorectal Cancer Cells by Targeting FDX1. Journal of the American Chemical Society. 2025, in press. IF=15.6
2. Pengli Huang#, Rui Jing#, Wendan Zhang#, Jun Xia#, Xin Luan, Ji Ye, Saisai Tian, Hao Zhang, Qun Wang, Honghong Jiang, Ningbo Wu, Mengting Xu, Guangyong Zheng, Dong Lu, Fei Qian, Tao Cheng, Weian Yuan, Feng Liu*, Sanhong Liu*, Weidong Zhang*. Icaritin Improves the Hematopoiesis-Supportive Function of MSCs via A PRDX1–MAPK Axis After Chemotherapy. Engineering. 2025, doi.org/10.1016/j.eng.2025.08.019. IF=11.6
3. Xiangxin Geng#, Minchen Cai#, Hongmei Hu#, Mengting Xu, Qing Zhang, Hanchen Xu, Dianping Yu, Hongwei Zhang, Hanchi Xu, Linyang Li, Mengmeng Guo, Shize Xie, Qun Wang*, Weidong Zhang*, Sanhong Liu*. Cordycepin targets HRD1 to promote cancer cell PD-L1 ubiquitin proteasome degradation and increase antitumor immunity. MedComm. 2025, in press. IF=10.7
4. Dianping Yu#, Hongmei Hu#, Qing Zhang#, Chengji Wang#, Mengting Xu, Hanchen Xu, Xiangxin Geng, Minchen Cai, Hongwei Zhang, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Sheng Lin*, Qun Wang*, Weidong Zhang*, Sanhong Liu*. Acevaltrate as a novel ferroptosis inducer with dual targets of PCBP1/2 and GPX4 in colorectal cancer. Signal Transduction and Targeted Therapy. 2025. 10(1):211. 2025第十四届上海药理青年论文报告会优秀论文特等奖，IF=52.7
5. Hongmei Hu#, Qun Wang#, Dianping Yu#, Mengmeng Guo, Xiaoyu Tao, Saisai Tian, Qing Zhang, Mengting Xu, Xiangxin Geng, Hongwei Zhang, Hanchi Xu, Linyang Li, Shize Xie, Kaixian Chen, Weiliang Zhu, Xu-Wen Li, Hanchen Xu*, Bo Li*, Weidong Zhang*, Sanhong Liu*. Berberine Derivative B68 Promotes Tumor Immune Clearance by Dual-Targeting BMI1 for Senescence Induction and CSN5 for PD-L1 Degradation. Advanced Science. 2025.12(7):e2413122. 封面文章， IF=14.1
6. Saisai Tian#, Mengting Xu#, Xiangxin Geng#, Jiansong Fang, Hanchen Xu, Xinying Xue, Hongmei Hu, Qing Zhang, Dianping Yu, Mengmeng Guo, Hongwei Zhang, Jinyuan Lu, Yangcheng Guo, Qun Wang*, Sanhong Liu*, Weidong Zhang*. Network Medicine-Based Strategy Identifies Maprotiline as a Repurposable Drug by Inhibiting PD-L1 Expression via Targeting SPOP in Cancer. Advanced Science. 2025. 12(1):e2410285. IF=14.1
7. Qun Wang#, Jinxin Wang#, Dianping Yu#, Qing Zhang#, Hongmei Hu, Mengting Xu, Hongwei Zhang, Saisai Tian, Guangyong Zheng, Dong Lu, Jiajia Hu, Mengmeng Guo, Minchen Cai, Xiangxin Geng, Yanyan Zhang, Jianhua Xia, Xin Zhang, Ang Li, Sanhong Liu*, Weidong Zhang*. Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell Reports Medicine. 2024. 5(2):101357. 封面文章，ESI前1%高被引论文，IF=11.7
8. Yanyan Zhang#, Yun Huang#, Dianping Yu, Mengting Xu, Hongmei Hu, Qing Zhang, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Jianhua Xia, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang*, Sanhong Liu*, Weidong Zhang*. Demethylzeylasteral induces PD-L1 ubiquitin-proteasome degradation and promotes antitumor immunity via targeting USP22. Acta Pharm Sin B. 2024.14(10):4312-4328. 2024第十三届上海药理青年论文报告会优秀论文一等奖，IF=14.7
9. Jianhua Xia#, Mengting Xu#, Hongmei Hu, Qing Zhang,Dianping Yu, Minchen Cai, Xiangxin Geng, Hongwei Zhang, Yanyan Zhang, Mengmeng Guo, Dong Lu, Hanchi Xu, Linyang Li, Xing Zhang, Qun Wang*, Sanhong Liu*, Weidong Zhang*. 5,7,4'-trimethoxyflavone triggers cancer cell PD-L1 ubiquitin-proteasome degradation and facilitates antitumor immunity by targeting HRD1. MedComm. 2024. 5(7):e611. 2024年Wiley出版社中国高贡献作者奖，IF=10.7
10. Wendan Zhang#, Honghong Jiang#, Gaosong Wu#, Pengli Huang#, Haonan Wang*, Huazhang An*, Sanhong Liu*, Weidong Zhang*. The pathogenesis and potential therapeutic targets in sepsis. MedComm. 2023. 4: e418. IF=10.7
11. Chao Lv#, Yun Huang#, Qun Wang#, Chengji Wang#, Hongmei Hu, Hongwei Zhang, Dong Lu, Honghong Jiang, Ruling Shen, Weidong Zhang*, Sanhong Liu*. Ainsliadimer A induces ROS-mediated apoptosis in colorectal cancer cells via directly targeting peroxiredoxin 1 and 2. Cell Chemical Biology, 2023. 30: 295-307. 封面文章， IF=7.2
12. Panpan Fu#, Qun Wang#, Qing Zhang#, Yang Jin, Jin Liu, Kaixian Chen, Yuewei Guo*, Sanhong Liu*, Xuwen Li*. Bioactivity-Driven Synthesis of Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting PD-L1. Journal of Medicinal Chemistry, 2023. doi: 10.1021/acs.jmedchem.2c01702. IF=6.8
13. Ye D#, Liu H#, Zhao G#, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S*, Liu S*, Zhang X*. LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis. Cell Death & Disease. 2023. 14(2):165. IF=9.6
14. Yuanyuan Gong#, Zukai Liu#, Yihang Yuan#, Zhenzhen Yang#, Jiawei Zhang, Qin Lu, Wei Wang, Chao Fang*, Haifan Lin*, Sanhong Liu*. PUMILIO proteins promote colorectal cancer growth via suppressing p21. Nature Communications. 2022. 13(1):1627. IF=15.7
15. Jiang Y#, Li F#, Gao B#, Ma M, Chen M, Wu Y, Zhang W, Sun Y*, Liu S*, Shen H*. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. Theranostics. 2021. 11: 3868-3881. 封面文章，IF=13.3
16. Gu WJ#, Shen YW#, Zhang LJ, Zhang H, Nagle DG, Luan X*, Liu SH*. The multifaceted involvement of exosomes in tumor progression: Induction and inhibition. MedComm. 2021 Jul 1;2(3):297-314. IF=10.7
17. Zang X#, Wang Q#, Zhou H#, Liu S*, Xue X*. Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study. Intensive Care Medicine. 2020. 46: 1927-1929. IF=21.2
18. Xue XY#, Liu YX#, Wang C#, Gu XJ#, Xue ZQ, Zang XL, Ma XD, Deng H, Liu R*, Pan L*, Liu SH*. Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma. Signal Transduction and Targeted Therapy. 2020. 5: 77. IF=52.7
19. Chen X#, Wang C#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin EY, Chen S, Liu Y, Wang M, Liu S*, Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy. 2020. 5: 52. 封面文章，IF=52.7
20. Liu S#*, Wang Z#, Liu Z#, Shi S, Zhang Z, Zhang J, Lin H*. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer. Journal of Molecular Cell Biology. 2018. 10: 302-315. 封面文章，IF=5.9
21. Ge QL#, Liu SH#, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR*, Teng YC*. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis. Cell Death & Disease. 2016. 7: e2402. IF=9.6
22. Liu S#, Sun X#, Wang M#, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 2014. 147: 847-859.e811. IF=25.1
实验室成员
2025级：陶晓玉（博士）、沈佳琪（硕士）、王希瑞（硕士）
2024级：李欣茹（硕士）、李思梦（硕士）
2023级：许寒池（硕士）、李林洋（硕士）、于典平（联培博士）
2022级：胡洪梅（博士、已毕业）、许梦婷（硕博连读）、耿向欣（硕士、已毕业）
2021级：蔡闵晨（硕士、已毕业）、张清（硕博连读）、夏俭华（联培硕士、已毕业）、张炎炎（联培硕士、已毕业）
2020级：于典平（联培硕士、毕业读博）、黄昀（联培硕士、已毕业）、王红茹（联培硕士、已毕业）