个人简介

        办公电话：13166300770

       电子邮箱：zhoumm368@163.com

       通讯地址：上海市浦东新区蔡伦路1200号82号信箱2号楼2325室

       研究方向：基于代谢组和肠道菌的中药药理学研究；治疗抑郁症及代谢相关疾病的中药研究

招生专业

教育及任职经历

       2023/12-今,             上海中医药大学，交叉科学研究院中医药表型组学研究中心，研究员

       2021/12-2023/12,   上海中医药大学，交叉科学研究院中医药表型组学研究中心，副研究员

       2016/10-2021/12,   上海中医药大学，交叉科学研究院中医方证与系统生物学研究中心，副研究员

       2008/12-2016/10,   上海中医药大学，中医药研究院中医方证与系统生物学研究中心，副研究员

       2014/04-2015/06,   上海交通大学第六人民医院转化医学中心进修

       2004/09-2008/12，上海中医药大学，中医药研究院中医方证与系统生物学研究中心，助理研究员

       2002/07-2004/09，中科院上海药物研究所，中药药代研究与多成分分析课题组，博士后

       1999/07-2002/07，成都中医药大学药学院，中药学，博士

       1995/07-1998/07，成都中医药大学药学院，药理学，硕士 

       1991/09-1995/07，成都中医药大学药学院，中药学，学士      

近五年以第一负责人承担的科研课题与经费

代表性文章 

1. Ruisi Liu, et al. Itaconate: A promising precursor for treatment of neuroinflammation associated depression. Biomed Pharmacother. 2023;167:115521. (共同通讯)

2. Jiawei Feng, et al. Exosomes: Potential key players towards novel therapeutic options in diabetic wounds. Biomed Pharmacother. 2023;166:115297. (共同通讯)

3. Ruisi Liu, et al. Brain and serum metabolomic studies reveal therapeutic effects of san hua decoction in rats with ischemic stroke. Front Endocrinol (Lausanne). 2023;14:1289558.  (共同通讯)

4. Yiming Ni, et al. Qushi Huayu decoction ameliorates non-alcoholic fatty liver disease in rats by modulating gut microbiota and serum lipids. Front Endocrinol (Lausanne). 2023;14:1272214.  (共同通讯)

5. Yiming Ni, et al. Therapeutic effect of Sanhua decoction on rats with middle cerebral artery occlusion and the associated changes in gut microbiota and short-chain fatty acids. PLoS One. 2024;19(2):e0298148. (共同通讯)

6. Siyuan Lin, et al. Wounds under diabetic milieu: The role of immune cellar components and signaling pathways. Biomedicine & Pharmacotherapy. 2023,157,114052.  (共同通讯)

7. 2.Dongdong Qian, et al. Identification of potential targets of cinnamon for treatment against Alzhermer’s disease-related GABAergic synaptic dysfunction using network pharmacology. Sci Rep. 2022, 12(1):19959.  (共同通讯)

8. Gen Li, et al. Recent insights into the role of defensins in diabetic wound healing. Biomed Pharmacother. 2022 Sep 12;155:113694. doi: 10.1016/j.biopha.2022.113694.  (共同通讯)

9. Xinyi Gu, et al. Investigation of Gynura segetum root extract (GSrE) induced hepatotoxicity based on metabolomic signatures and microbial community profiling in rats. Front. Microbiol. 13:947757. doi: 10.3389/fmicb.2022.947757.  (共同通讯)

10. Xinyi Gu, et al. Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder. Front. Cell Dev. Biol. 2022. 10:900637.  (共同通讯)

11. Qixue Wang, et al. The role of microglia immunometabolism in neurodegeneration: Focus on molecular determinants and metabolic intermediates of metabolic reprogramming. Biomedicine & Pharmacotherapy 153 (2022) 113412. (通讯作者)

12. Jiawei Feng, et al. Oxidative stress and lipid peroxidation: prospective associations between ferroptosis and delayed wound healing in diabetic ulcers. Front Cell Dev Biol. 2022;10:898657. doi: 10.3389/fcell.2022.898657. (共同通讯)

13. Qixue Wang, et al. Brain mitochondrial dysfunction: a possible mechanism links early life anxiety to Alzheimer’s disease in later life. Aging Dis. 2022;13(4):1127-1145. doi: 10.14336/AD.2022.0221. (通讯作者)

14. Yiming Ni, et al. The role of gut microbiota-bile acid axis in the progression of non-alcoholic fatty liver disease. Front Microbiol. 2022;13:908011. doi: 10.3389/fmicb.2022.908011. (共同通讯)

15. Xinyi Gu, et al. The impact of instant coffee and decaffeinated coffee on the gut microbiota and depression-like behavior of sleep-deprived rats. Front Microbiol. 2022;  doi:10.3389/fmicb.2022.778512.  (通讯作者)

16. Ying Li, et al. Investigation of amelioration effects of Pithecellobium clypearia Benth. On imiquimod-induced psoriasis in mice by tissue metabonomics analysis. Front Pharmacol. 2021; doi: 10.3389/fphar.2021.748772. (共同通讯)

17. Tongxi Zhuang, et al. Gut microbiota: novel therapeutic target of ginsenosides for the treatment of obesity and its complications. Front Pharmacol. 2021; 12:731288. doi: 10.3389/fphar.2021.731288. (共同通讯)

18. Jie Gao, et al. Urinary metabolomics changes and microbiotic alterations in presenilin1/2 conditional double knockout mice. J Transl Med. 2021; 19(1):351. doi: 10.1186/s12967-021-03032-9. (共同通讯)

19. Xinyi Gu, et al. Energy metabolism in major depressive disorder: recent advances from omics technologies and imaging. Biomed Pharmacother. 2021; 141:111869. Doi:10.1016/ j.biopha.2021.111869. (通讯作者)

20. Xinyi Gu, et al. Emerging application of metabolomics on Chinese herbal medicine for depressive disorder. Biomed Pharmacother. 2021; 141:111866. doi: 10.1016/j.biopha.2021.111866. (通讯作者)

21. Tongxi Zhuang, et al. Dose-related urinary metabolic alterations of a combination of quercetin and resveratrol-treated high-fat diet fed rats. Front Pharmacol. 2021; 12:655563. doi: 10.3389/ fphar.2021.655563. (通讯作者)

22. Yuqing Wang, et al. An update on potential biomarkers for diagnosing diabetic foot ulcer at early stage. Biomed Pharmacother. 2021; 133:110991. doi: 10.1016/j.biopha.2020.110991. (共同通讯)

23. Jiaxin Zong, et al. Serum Metabolomic profiling reveals the amelioration effect of methotrexate on imiquimod-induced psoriasis in mouse. Front Pharmacol. 2020; 11: 558629. doi: 10.3389/fphar.2020.558629. (共同通讯)

24. Tongxi Zhuang, et al. Hepatoprotection and hepatotoxicity of Chinese herb Rhubarb (Dahuang): How to properly control the “General (Jiang Jun)” in Chinese medical herb. Biomed Pharmacother. 2020; 127:110224. (共同通讯)

25. Nian Zhou, et al. Gut microbiota: a provital hub for polyphenols as antidepressants. J Agric Food Chem. 2020; 68(22): 6007-6020. (共同通讯)

26. Xiaowen Shi, et al. Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis. BMC Pharmacol Toxicol. 2019; 20(1):56. (共同通讯)

27. Weini Ma, et al. Chronic paradoxical sleep deprivation-induced depressionlike behavior, metabolic and microbial changes in rats. Life Sciences, 2019; 225:88-97. (通讯作者)

28. Jing Song, et al. Metabolomic signatures and microbial community profiling of depressive rat model induced by adrenocorticotrophic hormone. J Transl Med. 2019; 17(1):224. (通讯作者)

    Jing Song, et al.  Modulation of gut microbiota by chlorogenic acid pretreatment on rats with adrenocorticotrpic hormone induced depression-like behavior. Food Funct. 2019;10(5): 2947-2957. (通讯作者)

29. Le Zhao, et al. A urinary metabolomics (GC-MS) Strategy to evaluate antidepressant-like effect of chlorogenic acid in adrenocorticotropic hormone-treated rats. RSC advances, 2018, 8, 9141-9151. (共同通讯)

30. Wei-ni Ma, et al. Urinary metabolomic study of chlorogenic acid in a rat model of chronic sleep deprivation using gas chromatography-mass spectrometry. International Journal of Genomics.vol. 2018, Article ID 1361402, 11 pages, 2018. doi:10.1155/2018/1361402. (共同通讯)

31. Le Zhao, et al.  A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota. Food & Function, 2017, 13; 8(12):4644-4656. (通讯作者） 被Web of Science评为高被引论文

32. Le Zhao, et al. Combination treatment with quercetin and resveratrol attenuates high fat diet-induced obesity and associated inflammation in rats via the AMPKα1/SIRT1 signaling pathway. Experimental and Therapeutic Medicine, 2017, 14(6), 5942-5948.  (共同通讯)