张卫东 教授

发布者:交叉科学研究院-01发布时间:2022-07-05浏览次数:10366

招生专业

 

院系名称专业大类一级学科专业代码/专业名称学位类型招生类型
交叉科学研究院医学中药学100800/中药学学术学位博士/硕士
交叉科学研究院医学中药学105600/中药学专业学位硕士


教育及任职经历

1984.09-1988.07    第二军医大学药学院        获学士学位

1988.09-1991.07    第二军医大学药学院        获硕士学位

1995.09-1998.09    上海医药工业研究院        获博士学位

任职经历

担任第十届国家药典委员会天然药物专业委员会副主任委员,世界中医药学会联合会中药化学专业委员会副理事长,上海市药学会天然药物化学专业委员会副主任委员,国家中药标准化工程中心副主任,上海活性天然产物制备工程中心主任,《中国药典》英文版副主编。先后担任Journal of Pharmaceutical and Biochemical Analysis, Planta Medica, Fitoterapia等多本国际学术期刊和中文核心刊物《药学学报》、《中国中药杂志》的编委

目前以第一负责人承担的科研课题与经费

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课题类型

项目时间

项目经费

(万元)

备注

1上海市进一步加快中医药传承创新发展三年行动计划2021.09-2023.121309.44主持
2国家中医药多学科交叉创新团队项目2021.01-2023.12972

主持

代表性文章(第一/通讯作者)

1.  Qi S#, Guan X#, Zhang J#, Yu D, Yu X, Li Q, Yin W, Cheng XD*, Zhang WD*, Qin JJ*. Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis. Mol Cancer. 2022 Mar 10;21(1):70. (IF 41.44)

2.    Shen YW, Zhou YD, Chen HZ, Luan X*, Zhang WD*. Targeting CTGF in Cancer: An Emerging Therapeutic Opportunity. Trends Cancer. 2021 Jun;7(6):511-524. (IF 19.161)

3.    Luan X#, Wu Y#, Shen YW, Zhang H, Zhou YD, Chen HZ, Nagle DG*, Zhang WD*. Cytotoxic and antitumor peptides as novel chemotherapeutics. Nat Prod Rep. 2021 Jan 1;38(1):7-17. (IF 15.111)

4.   Huang R#, Zhang L#, Jin J#, Zhou Y, Zhang H, Lv C, Lu D, Wu Y, Zhang H, Liu S, Chen H*, Luan X*, Zhang WD*. Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction. Acta Pharm Sin B. 2021 Nov;11(11):3481-3492. (IF 14.903)

5.  Zheng N, Gu Y, Hong Y, Sheng L, Chen L, Zhang ,Hou J, Zhang WD, Jia W*, Li H*. Vancomycin pretreatment attenuates acetaminophen-induced liver injury through 2-hydroxybutyric acid. J Pharm Anal. 2020; (IF 14.026)

6.  Li S, Si C, Zhang WD*, Hu HG*.Stapled Helical Peptides Bearing Different Anchoring Residues. Chem Rev, 2020, 120(18):10079-10144. (IF 72.087)

7.    Shen YW, Zhou YD, Luan X*, Zhang WD*. Blocking CTGF-Mediated Tumor-Stroma Interplay in Pancreatic Cancer. Trends Mol Med. 2020 Dec;26(12):1064-1067. (IF 15.272)

8.    Jin J#, Qiu S#, Wang P, Liang X, Huang F, Wu H, Zhang B, Zhang WD, Tian X, Xu R*, Shi H*, Wu X. Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming. J Exp Clin Cancer Res. 2019;38(1):377. (IF 12.658)

9.    Bai F#, Liu K#, Li H#, Wang J, Zhu J, Hao P, Zhu L, Zhang S, Shan L, Ma W, Bode A, Zhang WD*, Li H*, Dong Z*. Veratramine modulates AP-1-dependent gene transcription by directly binding to programmable DNA. Nucleic Acids Res. 2018;46(2):546-557. (IF 19.160)

10. Qu Y, Olsen JR, Yuan X, Cheng PF, Levesque MP, Brokstad KA, Hoffman PS, Oyan AM, Zhang WD*, Kalland KH*, Ke X*. Small molecule promotes β-catenin citrullination and inhibits Wnt signaling in cancer. Nat Chem Biol. 2018 Jan;14(1):94-101. (IF 16.174)

11. Cui C, Zhou X, Zhang WD*, Qu Y*, Ke X*. Is β-Catenin a Druggable Target for Cancer Therapy?. Trends Biochem Sci. 2018;43(8):623-634. (IF 14.264)

12. Zhang Z#, Wang J#, Li J#, Yang F, Liu G, Tang W, He W, Fu JJ, Shen YH*, Li A*, Zhang WD*. Total Synthesis and Stereochemical Assignment of Delavatine A: Rh-Catalyzed Asymmetric Hydrogenation of Indene-Type Tetrasubstituted Olefins and Kinetic Resolution through Pd-Catalyzed Triflamide-Directed C-H Olefination. J Am Chem Soc. 2017 Apr 19;139(15):5558-5567. (IF 16.383)

13. Li X, Yang X, Liu Y, Gong N, Yao W, Chen P, Qin J, Jin H, Li J, Chu R, Shan L, Zhang R, Zhang WD*, Wang H*. Japonicone A suppresses growth of Burkitt lymphoma cells through its effect on NF-κB. Clin Cancer Res. 2013;19(11):2917-2928. (IF 13.801)