周钱梅 副研究员、硕士生导师
基本信息
电子邮箱：tazhou@163.com
办公电话：021-51323081
通讯地址：上海市浦东新区蔡伦路1200号2号楼2417室
研究方向
中医药抗肿瘤药理
中药复方及其成分减轻化疗药物副作用的分子机制研究
招生专业
院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 | 类型 |
交叉科学研究院 | 医学 | 中西医结合 | 100601/ 中西医结合基础 | 学术型 | 硕士 | 全日制 |
教育及任职经历
2013.01-至今, 上海中医药大学, 交叉科学研究院, 副研究员
2020.10-2021.10, 中国科学院上海药物研究所, 访问学者
2010.08-2012.12, 上海中医药大学, 学科办, 助理研究员
2006.09-2010.07, 上海中医药大学, 中西医结合基础, 博士
2003.09-2006.07, 安徽中医药大学, 方剂学, 硕士
1998.09-2003.07, 安徽中医药大学, 中医学, 学士
近五年以第一负责人承担的科研课题与经费
上海市自然科学基金，24ZR1466800，基于TFAM/mtDNA-STING调控线粒体稳态诠益气扶正法减轻顺铂肾损伤的作用机理，20万元。
干细胞与转化IV 类高峰学科科研项目，中药复方抑制肿瘤干细胞的基础研究，40万元。
国家自然基金青年基金，81803934，参芪扶正注射液调控PI3k信号通路活性抑制TAMs向M2过度极化及P-gp表达缓解三阴性乳腺癌化疗耐药机制研究，19万元。
第一/通讯作者代表性论文
(1) Zhang Y, Ma Y, Yue R, Meng Y, Jin Y, Yin C, Zhou Q, Shi R. Meningitis caused by Aspergillus fumigatus: a case report. BMC Infect Dis. 2025 Aug 21;25(1):1051.
(2) Liu D, Zhang Y, Bai B, Xiong X, Zhou Q, Shi R. Integration of single-cell RNA sequencing and network pharmacology to elucidate the effect of Yantiao Formula on alleviating ALI by regulating the polarization of alveolar macrophages. J Ethnopharmacol. 2025 Mar 13; 343: 119436.
(3) Zhu L, Liu D, Xu M, Wang W, Xiong X, Zhou Q, Shi R. Yantiao Formula Intervention in Rats with Sepsis: Network Pharmacology and Experimental Analysis. Comb Chem High Throughput Screen. 2024;27(7):1071-1080.
(4) Bufan Bai, Yingrui Ma, Deng Liu, Yifei Zhang, Weihong Zhang, Rong Shi, Qianmei Zhou. DNA damage caused by chemotherapy has duality, and traditional Chinese medicine may be a better choice to reduce its toxicity. Front Pharmacol. 2024, 15:1483160.
(5) Yingrui Ma, Bufan Bai, Deng Liu, Rong Shi, Qianmei Zhou. Shenqi Fuzheng Injection Reduces Cisplatin-Induced Kidney Injury via cGAS/STING Signaling Pathway in Breast Cancer Mice Model. Breast Cancer: Targets and Therapy. 2024, 16:16:451-469.
(6) 马颖瑞，白不凡，刘登，张艺菲，周钱梅. 联合网络药理学和转录组学探讨参芪扶正注射液减轻顺铂肾损伤的分子机制. 新中医，2024, 56(16): 185-194.
(7) 颜彬，马颖瑞，白不凡，刘登，周钱梅. 基于UPLC-Q-TOF-MS的参芪扶正注射液主要成分鉴定及其治疗三阴性乳腺癌的网络药理学研究, 上海中医药杂志, 2024, 58(2): 52-61.
(8) Yingrui Ma, Bufan Bai, Deng Liu, Rong Shi, Qianmei Zhou. Targeting the stimulator of interferon genes (STING) in breast cancer. Front Pharmacol, 2023, 14: 1199152.
(9) Bin Yan, Rong Shi, Yiyu Lu, Dongdong Fang, Qianmei Zhou. Shenqi Fuzheng injection reverses M2 macrophage-mediated cisplatin resistance through the PI3K pathway in breast cancer. PLoS One, 2023, 18(1): e0279752.
(10) 颜彬, 周钱梅. 肿瘤相关巨噬细胞参与化疗耐药及中医药干预研究进展. 中国实验方剂学杂志, 2021, 27(17): 193-202.
(11) Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Shi-Bing Su. Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis. CANCER CELL INTERNATIONAL, 2017, 17: 84.
(12) Jia Du, Yang Sun, Yi-Yu Lu, Eric Lau, Ming Zhao, Qian-Mei Zhou, Shi-Bing Su. Berberine and Evodiamine Act Synergistically Against Human Breast Cancer MCF-7 Cells by Inducing Cell Cycle Arrest and Apoptosis. ANTICAN CER RESEARCH, 2017, 37(37): 6141-6151.
(13) Qian-Mei Zhou, Qi-Long Chen, Jia Du, Xiu-Feng Wang, Yi-Yu Lu, Hui Zhang, Shi-Bing Su. Synergistic effect of combinatorial treatment withcurcumin and mitomycin C on the induction of apoptosis of breast cancer cells: a cDNA microarray analysis. International Journal of Molecular Sciences, 2014, 15(9): 16284-16301.
(14) Qian-Mei Zhou, Xiu-Feng Wang, Xin-Jun Liu, Hui Zhang, Yi-Yu Lu, Shi-Bing Su. Curcumin enhanced antiproliferative effect of mitomycin C in human breast cancer MCF-7 cells in vitro and in vivo. Acta Pharmacologica Sinica, 2011, 32(11): 1402-1410.
(15) Qian-Mei Zhou, Xiu-Feng Wang, Xin-Jun Liu, Hui Zhang, Yi-Yu Lu, Shuang Huang, Shi-Bing Su. Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects. European Journal of Cancer, 2011, 47(14): 2240-2247.