周钱梅 副研究员、硕士生导师
基本信息
电子邮箱：tazhou@163.com
办公电话：021-51323081
通讯地址：上海市浦东新区蔡伦路1200号2号楼2417室
研究方向
中医药抗肿瘤药理
中药复方及其成分的分子机制研究
招生专业
院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 | 类型 |
交叉科学研究院 | 医学 | 中西医结合 | 100601/ 中西医结合基础 | 学术型 | 硕士 | 全日制 |
教育及任职经历
2013.01-至今, 上海中医药大学, 交叉科学研究院, 副研究员
2020.10-2021.10, 中国科学院上海药物研究所, 访问学者
2010.08-2012.12, 上海中医药大学, 学科办, 助理研究员
2006.09-2010.07, 上海中医药大学, 中西医结合基础, 博士
2003.09-2006.07, 安徽中医药大学, 方剂学, 硕士
1998.09-2003.07, 安徽中医药大学, 中医学, 学士
近五年以第一负责人承担的科研课题与经费
国家自然基金青年基金, 81803934, 参芪扶正注射液调控PI3k信号通路活性抑制TAMs向M2过度极化及P-gp表达缓解三阴性乳腺癌化疗耐药机制研究, 19万元。
上海市教委预算内项目, 2016YSN16, 基于 IL-6/AP-1信号通路对乳腺癌干细胞生长与肿瘤相关巨噬浸润的影响探讨益气方改善耐药机理, 5万元。
上海市教委专项基金项目, 中西医结合B 类, 从抑制肿瘤干细胞自我更新角度探讨益气小复方逆转三阴性乳腺癌耐药的作用机制, 8万元。
第一/通讯作者代表性论文
颜彬, 周钱梅. 肿瘤相关巨噬细胞参与化疗耐药及中医药干预研究进展. 中国实验方剂学杂志, 2021, 27(17): 193-202.
Qian-Mei Zhou, Wei-Hong Zhang, Tian Li, Runwei Tang, Chaoran Li, Shuai Yuan, Desheng Fan. Formononetin Enhances the Tumoricidal Effect of Everolimus in Breast Cancer MDA-MB-468 Cells by Suppressing the mTOR Pathway. Evid Based Complement Alternat Med, 2019, 2019: 961062.
Qian-Mei Zhou, Yang Sun, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Shi-Bing Su. Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis. CANCER CELL INTERNATIONAL, 2017, 17: 84.
Jia Du, Yang Sun, Yi-Yu Lu, Eric Lau, Ming Zhao, Qian-Mei Zhou, Shi-Bing Su. Berberine and Evodiamine Act Synergistically Against Human Breast Cancer MCF-7 Cells by Inducing Cell Cycle Arrest and Apoptosis. ANTICAN CER RESEARCH, 2017, 37(37): 6141-6151.
Qian-Mei Zhou, Mei-Na Ye, Yi-Yu Lu, Hui Zhang, Qi-Long Chen, Shuang Huang, Shi-Bing Su. Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells. PLoS One, 2015, 10(8): e0136694.
Qian-Mei Zhou, Qi-Long Chen, Jia Du, Xiu-Feng Wang, Yi-Yu Lu, Hui Zhang, Shi-Bing Su. Synergistic effect of combinatorial treatment withcurcumin and mitomycin C on the induction of apoptosis of breast cancer cells: a cDNA microarray analysis. International Journal of Molecular Sciences, 2014, 15(9): 16284-16301.
Qian-Mei Zhou, Xiu-Feng Wang, Xin-Jun Liu, Hui Zhang, Yi-Yu Lu, Shi-Bing Su. Curcumin enhanced antiproliferative effect of mitomycin C in human breast cancer MCF-7 cells in vitro and in vivo. Acta Pharmacologica Sinica, 2011, 32(11): 1402-1410.
Qian-Mei Zhou, Xiu-Feng Wang, Xin-Jun Liu, Hui Zhang, Yi-Yu Lu, Shuang Huang, Shi-Bing Su. Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effects. European Journal of Cancer, 2011, 47(14): 2240-2247.
Qian-Mei Zhou, Song Wang, Hui Zhang, Yi-Yu Lu, Xiu-Feng Wang, Yoshiharu Motoo, Shi-Bing Su. Combination of baicalin and baicalein enhances apoptosis via ERK/p38 MAPK pathway in human breast cancer cells. ActaPharmacol Sin, 2009, 30(12): 1648-1658.
Qian-Mei Zhou, Hui Zhang, Yi-Yu Lu, Xiu-Feng Wang, Shi-Bing Su. Curcumin reduced the side effects of mitomycin C by inhibiting GRP58-mediated DNAcross-linking in MCF-7 breast cancer xenografts. Cancer Sci, 2009, 100(11): 2040-2045.