陈莉莉 研究员、硕士生导师
基本信息
办公电话:021-51322720
电子邮箱:llchen@shutcm.edu.cn
通讯地址:上海市浦东新区蔡伦路1200号创新楼9楼901室
招生专业
院系名称 | 专业大类 | 一级学科 | 专业代码/专业 名称 | 学位类型 | 招生类型 |
交叉科学研究院 | 医学 | 中药学 | 100800/中药学 | 学术学位 | 硕士 |
交叉科学研究院 | 医学 | 中药学 | 105600/中药学 | 专业学位 | 硕士 |
教育及任职经历
1994.9-1998.7 中国海洋大学 学士
1998.9-2001.7 中国海洋大学 硕士
2003.9-2006.7 中国科学院上海药物研究所 博士
2001.7-2009.8 中国科学院上海药物研究所研究实习员、助理研究员、高级工程师
2009.9-2014.1 中国科学院上海药物研究所 副研究员
2014.1-2015.1 Emory University 访问学者
2015.1-2018.12 中国科学院上海药物研究所 副研究员
2019.1-至今 上海中医药大学交叉科学研究院 研究员、硕士生导师
研究方向
1、创新药物研究
2、天然产物抗感染、抗肿瘤分子机制、信号通路以及化学生物学研究
近五年以第一负责人承担的科研课题与经费
序号 | 课题类型 | 项目时间 | 项目经费 (万元) | 备注 |
1 | 上海市科委自然科学基金面上项目 | 2020.07-2025.12 | 20 | 主持 |
2 | 上海卫健委中医药防治新冠肺炎科研项目 | 2020.02-2020.06 | 10 | 主持 |
3 | 上海中医药大学应急科研攻关项目 | 2020.02-2020.06 | 20 | 主持 |
4 | 上海中医药大学高水平大学人才引进 | 2021.05-2024.04 | 80 | 主持 |
代表性文章
Ye Wu, Rui Huang, Jin-Mei Jin, Li-Jun Zhang, Hong Zhang, Hong-Zhuan Chen, Li-Li Chen*, Xin Luan*. Advances in the Study of Structural Modification and Biological Activities of Anoplin. Front Chem. 2020, 8:519. (IF= 5.221)
Liqiang Ni#, Lili Chen#, Xia Huang#, Chouping Han, Hong Zhang, Xin Luan, Yongfang Zhao, Jianguang Xu, Weian Yuan*, Hongzhuan Chen*. Combating COVID-19 with integrated traditional Chinese and Western medicine in China. Acta Pharm Sin B. 2020,10(7):1149-1162. (IF=11.413)
Shaopeng Yu#, Yuying Zhu#, Jiaruo Xu, Guangtao Yao, Pei Zhang, Mengge Wang, Yongfang Zhao, Guoqiang Lin, Hongzhuan Chen*, Lili Chen*, Jiange Zhang*. Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2. Phytomedicine. 2021, 85:153364. (IF=5.34)
Yiming Yin, Mengge Wang, Wenjie Gu, Lili Chen*. Intestine-Specific FXR agonists as potential therapeutic agents for Colorectal Cancer. Biochem Pharmacol. 2021, 186:114430. (IF=5.858)
Ruyu Wang#, Qing Hu#, Haonan Wang, Guanghao Zhu, Mengge Wang, Qian Zhang, Yishu Zhao, Chunyu Li, Yani Zhang, Guangbo Ge*,Hongzhuan Chen*, Lili Chen*. Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CL. Int J Biol Macromol, 2021, 183:182-192. (IF=6.953)
Yusen Xiang, Mengge Wang, Hongzhuan Chen*, Lili Chen*. Potential therapeutic approaches for the early entry of SARS-CoV-2 by interrupting the interaction between the spike protein on SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2). Biochem Pharmacol. 2021, 192:114724. (IF=5.858)
Shaopeng Yu#, Yao Chen#, Yusen Xiang#, He Lin, Mengge Wang, Wenbo Ye, Pei Zhang, Hongzhuan Chen, Guoqiang Lin, Yuying Zhu, Lili Chen*, Jiange Zhang*. Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect. Phytother Res. 2021, 35(10):5847-5860. (IF=5.878)
Jiacheng Xiong#, Yusen Xiang#, Ziming Huang, Xiaohong Liu, Mengge Wang, Guangbo Ge, Hongzhuan Chen, Jianrong Xu*, Mingyue Zheng*, Lili Chen*. Structure-based virtual screening and identification of potential inhibitors of SARS-CoV-2 S-RBD and ACE2 interaction, Front Chem. 2021, 9:740702. (IF= 5.221)
Guang-Hui Ma#, Yan Ye#, Dan Zhang#, Xin Xu, Pei Si, Jian-Long Peng, Yong-Long Xiao, Rui-Yuan Cao, Yu-Ling Yin, Jing Chen, Lin-Xiang Zhao, Yu Zhou*, Wu Zhong, Hong Liu, Xiao-Min Luo*, Li-Li Chen*, Xu Shen. Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening. Eur J Med Chem. 2016, 124:981-991. (IF= 4.519)
Xing Xu, Xin Xu, Peng Liu, Zhi-yuan Zhu, Jing Chen, Hai-an Fu, Li-li Chen*, Li-hong Hu*, Xu Shen*. Structural Basis for Small Molecule NDB (N-Benzyl-N-(3-(tert-butyl)-4-hydroxyphenyl)-2,6-dichloro-4-(dimethylamino) Benzamide) as a Selective Antagonist of Farnesoid X Receptor α (FXRα) in Stabilizing the Homodimerization of the Receptor. J Biol Chem. 2015, 290(32):19888-99. (IF= 4.573)