陈莉莉 研究员

陈莉莉  研究员、硕士生导师

基本信息

办公电话：021-51322720

电子邮箱：llchen@shutcm.edu.cn

通讯地址：上海市浦东新区蔡伦路1200号创新楼9楼901室

招生专业

教育及任职经历

1994.9-1998.7       中国海洋大学               学士

1998.9-2001.7       中国海洋大学               硕士

2003.9-2006.7       中国科学院上海药物研究所       博士

2001.7-2009.8       中国科学院上海药物研究所       研究实习员、助理研究员、高级工程师

2009.9-2014.1        中国科学院上海药物研究所       副研究员

2014.1-2015.1         Emory University                                     访问学者

2015.1-2018.12       中国科学院上海药物研究所       副研究员

2019.1-至今    上海中医药大学交叉科学研究院     研究员

研究方向

中药抗病毒、抗感染活性成分研究及创新药物发现

近五年以第一负责人承担的科研课题与经费

代表性文章

1.         Ruyu Wang^#, Xuwen Chen^#, Hongtao Li, Xixiang Chen, Donghui Sun, Danmei Yu, Jiani Lu, Yuanyuan Xie, Qian Zhang, Jianrong Xu, Weidong Zhang, Hongzhuan Chen, Shunying Liu*, Lili Chen*. Danshensu Inhibits SARS-CoV-2 by Targeting Its Main Protease as a Specific Covalent Inhibitor and Discovery of Bifunctional Compounds Eliciting Antiviral and Anti‐inflammatory Activity. Int J Biol Macromol. 2024, 257(Pt 2):128623 (最后通讯, IF=8.200)

2.         Hongtao Li^#, Meng Sun^#, Fuzhi Lei^#, Jinfeng Liu, Xixiang Chen, Yaqi Li, Ying Wang, Jiani Lu, Danmei Yu, Yueqiu Gao, Jianrong Xu, Hongzhuan Chen, Man Li*, Zhigang Yi*, Xiao He*, Lili Chen*. Methyl rosmarinate is an allosteric inhibitor of SARS-CoV-2 3CL protease as a potential candidate against SARS-CoV-2 infection. Antiviral Res. 2024, 224:105841. (最后通讯, IF=7.600)

3.         Ruyu Wang^#, Guanglei Zhai^#, Guanghao Zhu^#, Mengge Wang, Xiaoyi Gong, Weidong Zhang, Guangbo Ge^*,Hongzhuan Chen^*, Lili Chen^*. Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses. Bioorg Chem. 2023, 130: 106264. (最后通讯, IF=5.307)

4.         Yusen Xiang^#, Guanglei Zhai^#, Mengge Wang, Xixiang Chen, Yaozong Li, Weidong Zhang, Guangbo Ge, Jianrong Xu^*, Hongzhuan Chen^*, Lili Chen^*. Ginkgolic acids inhibit SARS-CoV-2 and its variants by blocking the spike protein/ACE2 interplay. Int J Biol Macromol. 2023, 226:780-792. (最后通讯, IF=8.200)

5.         Mengge Wang, Yusen Xiang, Ruyu Wang, Lijun Zhang, Hong Zhang, Hongzhuan Chen, Xin Luan*, Lili Chen*. Dihydrotanshinone I Inhibits the Proliferation and Growth of Oxaliplatin-Resistant Human HCT116 Colorectal Cancer Cells. Molecules. 2022, 27(22):7774 (最后通讯, IF=4.927)

6.         Shaopeng Yu^#, Yuying Zhu^#, Jiaruo Xu, Guangtao Yao, Pei Zhang, Mengge Wang, Yongfang Zhao, Guoqiang Lin, Hongzhuan Chen^*, Lili Chen^*, Jiange Zhang^*. Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2. Phytomedicine. 2021, 85:153364. (共同通讯, IF=6.656)

7.         Ruyu Wang^#, Qing Hu^#, Haonan Wang, Guanghao Zhu, Mengge Wang, Qian Zhang, Yishu Zhao, Chunyu Li, Yani Zhang, Guangbo Ge^*,Hongzhuan Chen^*, Lili Chen*, Identification of Vitamin K3 and its analogues as covalent inhibitors of SARS-CoV-2 3CL. Int J Biol Macromol. 2021, 183:182-192. (最后通讯, IF=8.025)

8.          Shaopeng Yu^#, Yao Chen^#, Yusen Xiang^#, He Lin, Mengge Wang, Wenbo Ye, Pei Zhang, Hongzhuan Chen, Guoqiang Lin, Yuying Zhu, Lili Chen^*, Jiange Zhang^*, Pseudoephedrine and its derivatives antagonize wild and mutated severe acute respiratory syndrome-CoV-2 viruses through blocking virus invasion and antiinflammatory effect. Phytother Res. 2021, 35(10):5847-5860. (共同通讯, IF=6.388)

9.         Jiacheng Xiong^#, Yusen Xiang^#, Ziming Huang, Xiaohong Liu, Mengge Wang, Guangbo Ge, Hongzhuan Chen, Jianrong Xu^*, Mingyue Zheng^*, Lili Chen^*. Structure-based virtual screening and identification of potential inhibitors of SARS-CoV-2 S-RBD and ACE2 interaction, Front Chem. 2021, 9:740702. (最后通讯, IF= 5.545)

10.      Liqiang Ni^#, Lili Chen^#, Xia Huang^#, Chouping Han, Hong Zhang, Xin Luan, Yongfang Zhao, Jianguang Xu, Weian Yuan*, Hongzhuan Chen*. Combating COVID-19 with integrated traditional Chinese and Western medicine in China. Acta Pharm Sin B. 2020,10(7):1149-1162. (共同一作, IF=11.614)

研究生获奖