邹立伟 研究员

邹立伟 

研究员，硕士生导师，杏林学者 

  办公电话：021-51323182

  电子信箱：chemzlw@163.com

  通讯地址：上海市浦东新区蔡伦路1200号科技创新楼A816 

  主要研究方向：药物代谢酶检测新方法开发与应用、中药活性成分发现与成药性优化、中药-药物相互作用。先后在TrAC Trends in Analytical Chemistry, Biosensors & Bioelectronics, Acta Pharmaceutica Sinica B, ACS Sensors, Materials Science & Engineering C, Organic. Letters, European Journal of Medicinal Chemistry等国际知名期刊发表SCI论文60余篇，H因子24，引用>1800次。其中1篇为ESI热点论文，3篇为ESI高被引论文，1篇获2019 Acta Pharm Sin B. Outstanding Paper Award。已授权发明专利8项（含国际专利2项）。先后主持或参与“重大新药创制”国家重大专项、“中医药现代化研究”重点专项、国家自然科学基金、上海市自然科学基金等项目10项；作为项目负责人主持企业委托横向课题4项。参与编写《系统药代动力学》一部，英文专著《Pharmaceutical Biocatalysis》一部参。获“辽宁省自然科学学术成果”一等奖1项（排名第一），世界中医药学会联合会“中医药国际贡献奖—科技进步”二等奖1项（排名第三）。Journal of Medicinal Chemistry, Acta Pharmacologica Sinica, Bioorganic Chemistry, ChemMedChem等学术刊物审稿人。中国中药协会中药产品开发与培育专业委员会委员，中华中医药学会中药实验药理分会青年委员、药物代谢专业委员会第二届青年委员会委员，上海药理学会药物代谢专业委员会委员。入选上海中医药大学“杏林学者”、国家中医药管理局“中医药国际化骨干人才培养”项目。

2024.01-至今，上海中医药大学，交叉科学研究院，研究员

2022.12-至今，上海交通大学, 化学化工学院（周永丰团队），访问学者

2019.12-2020.11，上海浦东科技和经济委员会，生物医药和新材料处，挂职

2018.01-2023.12，上海中医药大学，交叉科学研究院，副研究员

2017.03-2017.12，上海中医药大学，交叉科学研究院，助理研究员

2014.07-2017.02，中国科学院大连化学物理研究所，生物技术部，博士后

2010.09-2014.06，大连理工大学，制药科学与技术学院，有机化学，博士

  2008.07-2010.07，大连富乐马生物科技有限公司（Italy Flamma R＆D Center）,药物研发工程师

2005.09-2008.06，辽宁师范大学，化学化工学院，有机化学，硕士

2001.09-2005.07，辽宁师范大学，化学化工学院，应用化学，学士

1. Yu Sun#, Jie Mu#, Yongchen Wang, Chengwei Lü*, Li-Wei Zou*, Rational synthesis of 1,3,4-thiadiazole based ESIPT-ffuorescent probe for detection of Cu2+ and H2S in herbs, wine and fruits, Analytica Chimica Acta, 2024, 1297, 342379. (IF = 6.1)

2. Hao Li#, Xiao-Dong Li#, Chao-Hua Yan, Zhen-Hua Ni, Mu-Han Lü*, Li-Wei Zou*, Ling Yang*, Rational design of a near-infrared fluorescent probe for monitoring butyrylcholinesterase activity and its application in development of inhibitors, Frontiers in Bioengineering and Biotechnology, 2024, 12, 1387146. (IF = 5.7)

3.  Ci-Qin Li, Jin-Hui Shi*, Jie Mu, An-Qi Wang, Li-Wei Zou*, and Guang-Bo Ge*, Licochalcone A Derivatives as Selective Dipeptidyl Peptidase 4 Inhibitors with Anti-Inflammatory Effects, Journal of Natural Products, 2023, 86, 1824-1831. (IF = 5.1)

4. Qiang Jin#, Li-Lin Song#, Le-Le Ding, Jing Zhang, Dan-Dan Wang, Yun-Qing Song, Li-Wei Zou*, Guang-Bo Ge*, High-throughput optical assays for sensing serine hydrolases in living systems and their applications, TrAC Trends in Analytical Chemistry, 2022, 152, 116620.  (IF = 14.9)

5. Jing Zhang#, Qiu-Sha Pan#, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun**, Li-Wei Zou*, Ling Yang, Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 371, 629-640. (IF = 5.2)

6. Pei-Fang Song#, Qui-Sha Pan#, Zhao-Hui Sun, Li-Wei Zou*, Ling Yang*, Fibroblast activation protein alpha: Comprehensive detection methods for drug target and tumor marker, Chemico-Biological Interactions, 2022, 354, 109830. (IF = 5.8)

7. Xing-Kai Qian#, Jing Zhang#, Xiao-Dong Li, Pei-Fang Song, Li-Wei Zou*, Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry, 2022, 29, 2167-2188. (IF = 4.7)

8. Dan-Dan Wang#, Xing-Kai Qian#, Hong-Xin Li, Gui-Hua Jia, Qiang Jin, Xin Luan, Ya-Di Zhu, Yi-Nan Wang, Jian Huang, Li-Wei Zou*, Guang-Bo Ge*, Ling Yang*, Sensing and imaging of exosomal CD26 secreted from cancer cells and 3D colorectal tumor model using a novel near-infrared fluorogenic probe, Materials Science & Engineering C, 2021, 130, 112472. (IF = 7.3)

9. Yun-Qing Song#, Qiang Jin#, Dan-Dan Wang, Li-Wei Zou*, Guang-Bo Ge*, Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism. Chemico-Biological Interactions, 2021, 345, 109566. (IF = 5.2)

10.  Dan-Dan Wang#, Li-Wei Zou#, Qiang Jin, Xiao-Qing Guan, Yang Yu, Ya-Di Zhu, Jian Huang, Peng Gao, Ping Wang, Guang-Bo Ge*, Ling Yang*, A bioluminescent sensor reveals that carboxylesterase 1A is a novel endoplasmic reticulum-derived serologic indicator for hepatocyte injury, ACS Sensors, 2020, 5, 1987-1995. (IF = 8.9)

11. Yi-Shu Zhao#, Xing-Kai Qian#, Xiao-Qing Guan, Pei-Fang Song, Yun-Qing Song, Rong-Jing He, Meng-Ru Sun, Xiu-Yang Wang, Li-Wei Zou*, Guang-Bo Ge*. Discovery of natural alkaloids as potent and selective inhibitors against human carboxylesterase 2, Bioorganic Chemistry, 2020,105, 104367. (IF = 5.3)

12. Dan-Dan Wang#, Li-Wei Zou#, Qiang Jin, Jie Hou, Guang-Bo Ge*, Ling Yang, Human carboxylesterases: a comprehensive review, Acta Pharmaceutica Sinica B, 2018, 8, 699-712. (IF = 14.5, ESI高被引论文)

13. Xiao-Ze Bao, Shi-Qiang Wei, Xing-Kai Qian, Jing-Ping Qu, Bao-Min Wang*, Li-Wei Zou*, Guang-Bo Ge, Asymmetric Construction of a Multi-pharmacophore-containing dispirotriheterocyclic scaffold and identification of a human carboxylesterase 1 inhibitor, Organic Letters, 2018, 20, 3394-3398. (IF = 6.6)

14. Li-Wei Zou#, Qiang Jin#, Dan-Dan Wang, Da-Cheng Hao, Guang-Bo Ge*, Ling Yang, Carboxylesterase inhibitors: an update, Current Medicinal Chemistry, 2018, 25, 1627-1649. (IF = 4.1, ESI高被引论文)

15. Li-Wei Zou#, Ping Wang#, Xing-Kai Qian, Lei Feng, Yang Yu, Dan-Dan Wang, Qiang Jin, Jie Hou, Zhi-Hong Liu, Guang-Bo Ge*, Ling Yang*, A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems, Biosensors & Bioelectronics, 2017, 90, 283-289. (IF = 12.6)

1.张静，2019级硕士

Ø 获得荣誉： 

2022，上海市优秀毕业生 

2021，上海中医药大学优秀团员

2021，上海中医药大学优秀学生

2021，上海中医药大学一等奖学金

2021，上海“中医药的传承与创新”研究生论坛二等奖

2021，第七届上海大学生创新创业成果展“优秀项目报告奖”

2021，第六届“浦江 DMPK 论坛”优秀奖

Ø 发表论文： 

1. Hong-Hong Ma#, Jing Zhang#, Ci-Qin Li, Li-Wei Zou*, Discovery of anthraquinones as DPP-IV inhibitors: structure-activity relationships and inhibitory mechanism, Fitoterapia, 2023, 168, 105549. 

2. Jing Zhang#, Qiu-Sha Pan#, Xing-Kai Qian, Xiang-Lu Zhou, Ya-Jie Wang, Rong-Jing He, Le-Tian Wang, Yan-Ran Li, Hong Huo, Cheng-Gong Sun, Lei Sun**, Li-Wei Zou*, Ling Yang, Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1, Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 371, 629-640.

3. Xing-Kai Qian#, Jing Zhang#, Xiao-Dong Li, Pei-Fang Song, Li-Wei Zou*, Research Progress on Dipeptidyl Peptidase Family: Structure, Function and Xenobiotic Metabolism. Current Medicinal Chemistry, 2022, 29, 2167-2188. 

4. Jing Zhang#, Ci-Qin Li#, Li-Juan Tian, Xing-Kai Qian, An-Qi Wang, Shi-Yang Li, Cong-Cong Zhang*, Li-Wei Zou*, Study on the Inhibition of Six Kinds of Hypoglycemic Chinese Patent Medicines on Dipeptidyl Peptidase-IV, Integrative Food, Nutrition and Metabolism, 2022, 9, 1-8.

5. Jing Zhang, Xing-Kai Qian, Pei-Fang Song, Xiao-Dong Li, An-Qi Wang, Hong Huo, Jing-Chun Yao, Gui-Min Zhang* and Li-Wei Zou*, A high-throughput screening assay for dipeptidyl peptidase-IV inhibitors using human plasma, Analytical Methods, 2021, 13, 2671-2678. 

6. Xing-Kai Qian#, Jing Zhang#, Pei-Fang Song, Yi-Su Zhao, Hong-Ying Ma, Qiang Jin, Dan-Dan Wang, Xiao-Qing Guan, Shi-Yang Li, XiaoZe Bao*, Li-Wei Zou*, Discovery of Pyrazolones as Novel Carboxylesterase 2 Inhibitors that Potently Inhibit the Adipogenesis in Cells, Bioorganic & Medicinal Chemistry, 2021, 40, 116187.

7. Jing Zhang#, Yang Yang#, Xing-Kai Qian, Pei-Fang Song, Yi-Shu Zhao, Xiao-Qing Guan*, Li-Wei Zou*, Xiaoze Bao*, and Hong Wang. Design Synthesis and Structure Activity Relationship Study of Pyrazolones as Potent Inhibitors against Pancreatic Lipase, ChemMedChem, 2021, 16(10), 1600-1604.

Ø 专利申请： 

1. 邹立伟，张静，宋培放，李小东，王安琪，李嫣然，虎杖水提物及其成分在制备防治糖尿病的药物中的应用，专利申请号：20211045618852.

2. 邹立伟，张静，李小东，宋培放，王安琪，王乐天，黄连水提物及其成分在制备防治糖尿病的药物中的应用，专利申请号：20211045318703.

3. 邹立伟，王丹丹，钱星凯，张静，杨凌，葛广波，金强，宋培放，1-环己基吡唑啉酮类羧酸酯酶1抑制剂及其应用，专利申请号：202011182707.