刘三宏 研究员

1997.09-2001.07　河南农业大学                                   学士

2001.09-2004.06　中国农业科学院                                硕士

2004.09-2008.01　中国农业科学院                                博士

2008.02-2015.02　中国科学院上海生命科学研究院　　助理研究员、博士后、副研究员

2015.03-2020.06　上海科技大学免疫化学研究所　　　副研究员

2020.07-至今　　  上海中医药大学交叉科学研究院　　研究员、博士生导师

代表性文章

1.   Qun Wang#, Jinxin Wang#, Dianping Yu#, Qing Zhang#, Hongmei Hu, Mengting Xu, Hongwei Zhang, Saisai Tian, Guangyong Zheng, Dong Lu, Jiajia Hu, Mengmeng Guo, Minchen Cai, Xiangxin Geng, Yanyan Zhang, Jianhua Xia, Xin Zhang, Ang Li, Sanhong Liu*, Weidong Zhang*. Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3. Cell Reports Medicine. 2023. 已接收. IF=14.3

2.    Wendan Zhang#, Honghong Jiang#, Pengli Huang#, Gaosong Wu, Qun Wang, Xin Luan, Hongwei Zhang, Dianping Yu, Hongru Wang, Dong Lu, Haonan Wang*, Huazhang An*, Sanhong Liu*, Weidong Zhang*. Dracorhodin targeting CMPK2 attenuates inflammation: A novel approach to sepsis therapy. Clinical and Translational Medicine. 2023. 13: e1449. IF=10.6

3.   Wendan Zhang#, Honghong Jiang#, Gaosong Wu#, Pengli Huang#, Haonan Wang*, Huazhang An*, Sanhong Liu*, Weidong Zhang*. The pathogenesis and potential therapeutic targets in sepsis. MedComm. 2023. 4: e418. IF=9.9

4.    Chao Lv#, Yun Huang#, Qun Wang#, Chengji Wang#, Hongmei Hu, Hongwei Zhang, Dong Lu, Honghong Jiang, Ruling Shen, Weidong Zhang*, Sanhong Liu*. Ainsliadimer A induces ROS-mediated apoptosis in colorectal cancer cells via directly targeting peroxiredoxin 1 and 2. Cell Chemical Biology, 2023. 30: 295-307. 封面文章，IF=9.039

5.   Panpan Fu#, Qun Wang#, Qing Zhang#, Yang Jin, Jin Liu, Kaixian Chen, Yuewei Guo*, Sanhong Liu*, Xuwen Li*. Bioactivity-Driven Synthesis of Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting PD-L1. Journal of Medicinal Chemistry, 2023. doi: 10.1021/acs.jmedchem.2c01702. IF=8.039

6.    Ye D#, Liu H#, Zhao G#, Chen A, Jiang Y, Hu Y, Liu D, Xie N, Liang W, Chen X, Zhang H, Li C, Wang J, Sun D, Chen W, Tan D, Wang Q, Wang H, Yu D, Wu B, Wang M, Cui S*, Liu S*, Zhang X*. LncGMDS-AS1 promotes the tumorigenesis of colorectal cancer through HuR-STAT3/Wnt axis. Cell Death and Disease. 2023. 14(2):165. IF=9.685

7.   Yuanyuan Gong#, Zukai Liu#, Yihang Yuan#, Zhenzhen Yang#, Jiawei Zhang, Qin Lu, Wei Wang, Chao Fang*, Haifan Lin*, Sanhong Liu*. PUMILIO proteins promote colorectal cancer growth via suppressing p21. Nature Communications. 2022. 13(1):1627. IF=17.694

8.   Yun Zhang, Shuaijun Li, Peisheng Jin, Ting Shang, Ruizhu Sun, Laiya Lu, Kaijin Guo, Jiping Liu, Yuanjuan Tong, Junbang Wang, Sanhong Liu, Chen Wang, Yubing Kang, Wenmin Zhu, Qian Wang, Xiaoren Zhang, Feng Yin, Yi Sun*, Lei Cui*. Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis, Nature Communications. 2022. 4;13(1):2447. IF=17.694

9.    Zhang H#, Hu Y#, Liu D#, Liu Z, Xie N, Liu S, Zhang J, Jiang Y, Li C, Wang Q, Chen X, Ye D, Sun D, Zhai Y, Yan X, Liu Y, Chen CD, Huang X, Eugene Chin Y, Shi Y, Wu B, Zhang X*. The histone demethylase Kdm6b regulates the maturation and cytotoxicity of TCRαβ+CD8αα+ intestinal intraepithelial lymphocytes. Cell Death and Differentiation. 2022. 10.1038/s41418-021-00921-w. IF=12.067

10.    Jin J#, Wu Y#, Zhao Z#, Wu Y, Zhou YD, Liu S, Sun Q, Yang G, Lin J, Nagle DG, Qin J, Zhang Z, Chen HZ, Zhang W, Sun S, Luan X*. Small-molecule PROTAC mediates targeted protein degradation to treat STAT3-dependent epithelial cancer. JCI Insight. 2022. 7(22):e160606. IF=9.484

11.   Chao Lv#, Yun Huang#, Rui Huang, Qun Wang, Hongwei Zhang, Jinmei Jin, Dong Lu, Yudong Zhou, Yunheng Shen, Weidong Zhang*, Xin Luan*, Sanhong Liu*. Narciclasine targets STAT3 via distinct mechanisms in tamoxifen-resistant breast cancer cells. Molecular Therapy-Oncolytics. 2022. 24: 340-354. IF=6.311

12.   Huang R#, Zhang LJ#, Jin JM#, Zhou YD, Zhang HW, Lv C, Lu D, Wu Y, Zhang H, Liu SH, Chen HZ, Luan X*, Zhang WD*. Bruceine D inhibits HIF-1a-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction. Acta Pharm Sin B. 2021. 11(11):3481-3492. IF=14.903

13.    Hu Y#, Zhang H#, Xie N, Liu D, Jiang Y, Liu Z, Ye D, Liu S, Chen X, Li C, Wang Q, Huang X, Liu Y, Shi Y, Zhang X*. Bcl-3 promotes TNF-induced hepatocyte apoptosis by regulating the deubiquitination of RIP1. Cell Death and Differentiation. 2021. 10.1038/s41418-021-00908-7. IF=12.067

14. Jiang Y#, Li F#, Gao B#, Ma M, Chen M, Wu Y, Zhang W, Sun Y*, Liu S*, Shen H*. KDM6B-mediated histone demethylation of LDHA promotes lung metastasis of osteosarcoma. Theranostics. 2021. 11: 3868-3881. 封面文章，IF=11.6

15.  Chen Y#, Fang Z#, Tang Y#, Jin Y#, Guo C#, Hu L, Xu Y, Ma X, Gao J, Xie M, Zang X, Liu S, Chen H, Thomas RK, Xue X*, Ji H*, Chen L*. Integrative analysis of multi-omics data reveals the heterogeneity and signatures of immune therapy for small cell lung cancer. Clinical and Translational Medicine. 2021. 11(12), e620. IF=11.492

16.  Wu Y#, Lu D#, Jiang Y, Jin J, Liu S, Chen L, Zhang H, Zhou Y, Chen H, Nagle DG, Luan X*, Zhang W*. Stapled Wasp Venom-Derived Oncolytic Peptides with Side Chains Induce Rapid Membrane Lysis and Prolonged Immune Responses in Melanoma. Journal of Medicinal Chemistry. 2021. 64: 5802-5815. 封面文章，IF=8.039

17.  Peng W#, Chang M#, Wu Y#, Zhu W#, Tong L#, Zhang G, Wang Q, Liu J, Zhu X, Cheng T, Li Y, Chen X, Weng D, Liu S, Zhang H, Su Y, Zhou J*, Li H*, Song Y*. Lyophilized powder of mesenchymal stem cell supernatant attenuates acute lung injury through the IL-6-p-STAT3-p63-JAG2 pathway. Stem Cell Research & Therapy. 2021. 12: 216. IF=8.079

18.  Zhang HW#, Lv C#, Zhang LJ, Guo X, Shen YW, Nagle DG, Zhou YD, Liu SH*, Zhang WD*, Luan X*. Application of omics- and multi-omics-based techniques for natural product target discovery. Biomedicine & Pharmacotherapy. 2021. 141: 111833. IF=7.419

19.  Zang X#, Wang Q#, Zhou H#, Liu S*, Xue X*. Efficacy of early prone position for COVID-19 patients with severe hypoxia: a single-center prospective cohort study. Intensive Care Medicine. 2020. 46: 1927-1929. IF=41.787

20.  Xue XY#, Liu YX#, Wang C#, Gu XJ#, Xue ZQ, Zang XL, Ma XD, Deng H, Liu R*, Pan L*, Liu SH*. Identification of exosomal miRNAs as diagnostic biomarkers for cholangiocarcinoma and gallbladder carcinoma. Signal Transduction and Targeted Therapy. 2020. 5: 77. IF=38.104

21.  Chen X#, Wang C#, Jiang Y, Wang Q, Tao Y, Zhang H, Zhao Y, Hu Y, Li C, Ye D, Liu D, Jiang W, Chin EY, Chen S, Liu Y, Wang M, Liu S*, Zhang X*. Bcl-3 promotes Wnt signaling by maintaining the acetylation of β-catenin at lysine 49 in colorectal cancer. Signal Transduction and Targeted Therapy. 2020. 5: 52. 封面文章，IF=38.104

22.  Shi S, Yang ZZ, Liu S, Yang F, Lin H*. PIWIL1 promotes gastric cancer via a piRNA-independent mechanism. Proc Natl Acad Sci U S A. 2020. 117: 22390-22401. IF=12.779

23.  Wang Q#, Chen X#, Jiang Y#, Liu S, Liu H, Sun X, Zhang H, Liu Z, Tao Y, Li C, Hu Y, Liu D, Ye D, Liu Y, Wang M*, Zhang X*. Elevating H3K27me3 level sensitizes colorectal cancer to oxaliplatin. Journal of Molecular Cell Biology. 2020. 12: 125-137. IF=8.185

24.  Jiang Y#, Li C#, Wu Q#, An P, Huang L, Wang J, Chen C, Chen X, Zhang F, Ma L, Liu S, He H, Xie S, Sun Y, Liu H, Zhan Y, Tao Y, Liu Z, Sun X, Hu Y, Wang Q, Ye D, Zhang J, Zou S, Wang Y, Wei G, Liu Y, Shi Y, Eugene Chin Y, Hao Y, Wang F*, Zhang X*. Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses. Nature Communications. 2019.10: 2935. IF=17.694

25. Tao Y#, Liu Z#, Hou Y, Wang S, Liu S, Jiang Y, Tan D, Ge Q, Li C, Hu Y, Liu Z, Chen X, Wang Q, Wang M*, Zhang X*. Alternative NF-κB signaling promotes colorectal tumorigenesis through transcriptionally upregulating Bcl-3. Oncogene. 2018. 37: 5887-5900. IF=8.756

26. Liu S#*, Wang Z#, Liu Z#, Shi S, Zhang Z, Zhang J, Lin H*. miR-221/222 activate the Wnt/β-catenin signaling to promote triple-negative breast cancer. Journal of Molecular Cell Biology. 2018. 10: 302-315. 封面文章，IF=8.185

27.  Ge QL#, Liu SH#, Ai ZH, Tao MF, Ma L, Wen SY, Dai M, Liu F, Liu HS, Jiang RZ, Xue ZW, Jiang YH, Sun XH, Hu YM, Zhao YX, Chen X, Tao Y, Zhu XL, Ding WJ, Yang BQ, Liu DD, Zhang XR*, Teng YC*. RelB/NF-κB links cell cycle transition and apoptosis to endometrioid adenocarcinoma tumorigenesis. Cell Death and Disease. 2016. 7: e2402. IF=9.685

28.  Chen X#, Cao X#, Sun X, Lei R, Chen P, Zhao Y, Jiang Y, Yin J, Chen R, Ye D, Wang Q, Liu Z, Liu S, Cheng C, Mao J, Hou Y, Wang M, Siebenlist U, Eugene Chin Y, Wang Y, Cao L, Hu G, Zhang X*. Bcl-3 regulates TGFβ signaling by stabilizing Smad3 during breast cancer pulmonary metastasis. Cell Death and Disease. 2016. 7: e2508. IF=9.685

29.  Wang Z, Liu N, Shi S, Liu S*, Lin H*. The Role of PIWIL4, an Argonaute Family Protein, in Breast Cancer. Journal of  Biological Chemistry. 2016. 291: 10646-10658. F1000推荐论文，IF=5.486

30.  Liu Z#, Cao W#, Xu L, Chen X, Zhan Y, Yang Q, Liu S, Chen P, Jiang Y, Sun X, Tao Y, Hu Y, Li C, Wang Q, Wang Y, Chen CD*, Shi Y*, Zhang X*. The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation. Journal of Molecular Cell Biology. 2015. 7: 505-516. IF=8.185

31.  Liu S#, Sun X#, Wang M#, Hou Y, Zhan Y, Jiang Y, Liu Z, Cao X, Chen P, Liu Z, Chen X, Tao Y, Xu C, Mao J, Cheng C, Li C, Hu Y, Wang L, Chin YE, Shi Y, Siebenlist U, Zhang X*. A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells. Gastroenterology. 2014. 147: 847-859.e811. IF=33.883