研究员 博士生导师
基本信息
办公电话：021-51322408
电子邮箱：izhangdd@126.com
通讯地址：上海市浦东新区蔡伦路1200号2413室
研究方向：中药干预肿瘤微环境的机制研究
招生专业
院系名称 | 专业大类 | 一级学科 | 专业代码/专业名称 | 学位类型 | 招生类型 |
交叉科学研究院 | 医学 | 中药学 | 100800/中药学 | 学术学位 | 博士/硕士 |
交叉科学研究院 | 医学 | 中药学 | 105600/中药学 | 专业学位 | 硕士 |
教育及任职经历
2021.01-至今 上海中医药大学 研究员
2020.01-2020.05 美国耶鲁大学 高级访问学者
2011.01-2020.12 上海中医药大学 副研究员
2012.09-2013.08 美国乔治华盛顿大学 高级访问学者
2007.09-2010.12 上海中医药大学 助理研究员
2002.09-2007.07 上海中医药大学 博士
1998.09-2002.07 浙江师范大学 学士
研究方向
中药干预肿瘤微环境的机制研究。近年来围绕miRNAs在肿瘤增殖转移中的作用、巨噬细胞表型极化、肿瘤代谢及补气中药、清热解毒药对干预微环境的分子机制展开研究。
近五年以第一负责人承担的科研课题与经费
序号 | 课题类型 | 项目时间 | 项目经费 （万元） | 备注 |
1 | 国家自然科学基金面上项目 | 2018.01-2021.12 | 55 | 主持 |
2 | 国家自然科学基金面上项目 | 2016.01-2019.12 | 57 | 主持 |
代表性文章
1. Ya-Xin Lv, Hao-Ran Pan, Xin-Ying Song, Qing-Qi Chang, Dan-Dan Zhang *.Hedyotis diffusa plus Scutellaria barbata Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-κB/MAPK Signaling Pathways. Evid Based Complement Alternat Med.2021; 2021:6666499.
2. Ting Fang, Yi-Xin Jiang, Long Chen, Ling Huang, Xin-Hui Tian, Yu-Dong Zhou, Dale G Nagle, Dan-Dan Zhang*. Coix Seed Oil Exerts an Anti-Triple-Negative Breast Cancer Effect by Disrupting miR-205/S1PR1 Axis. Front Pharmacol. 2020; 11:529962.
3. Yue Yang, Ting Fang, Yi-Lan Cao, Ya-Xin Lv, Qing-Qi Chang, Dan-Dan Zhang *. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Breast Cancer Effect via miR-200c-PDE7B/PD-L1-AKT/MAPK Axis. Evid Based Complement Alternat Med. 2020; 2020:3587095.
4. Ting Fang, Ying-Xuan Yan, Yue Yang, Ya-Xin Lv, Qing-Qi Chang , Dan-Dan Zhang *. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Suppresses Migration of Bone-Metastatic Breast Cancer Cells via OPN-FAK/ERK/NF-κB Axis. Evid Based Complement Alternat Med. 2020; 2020:3573240.
5. Dan-Dan Zhang*, Yue Li, Yuan Xu, Jaejik Kim, shuang Huang*. Phosphodiesterase 7B/microRNA-200c relationship regulates triple-negative breast cancer cell growth. Oncogene.2019;38(7):1106-20.
6. Yi-Xin Jiang, Yan Chen, Yue Yang, Xiao-Xia Chen, Dan-Dan Zhang*.Screening Five Qi-Tonifying Herbs on M2 Phenotype Macrophages.Evid Based Complement Alternat Med. 2019; 2019: 9549315.
7. Yi-Xin Jiang, Yang-Yi Dai, Yi-Feng Pan, Xi-Min Wu, Yue Yang, Ka Bian, Dan-Dan Zhang*. Total Flavonoids from Radix Glycyrrhiza Exert Anti-Inflammatory and Antitumorigenic Effects by Inactivating iNOS Signaling Pathways. Evid Based Complement Alternat Med. 2018; 2018: 6714282.
8. Yuan Xu, Xiao-Xia Chen, Yi-Xin Jiang, Dan-Dan Zhang*. Ethyl Acetate Fraction from Hedyotis diffusa plus Scutellaria barbata Exerts Anti-Inflammatory Effects by Regulating miR-155 Expression and JNK Signaling Pathway.Evid Based Complement Alternat Med. 2018; 2018: 3593408.
9. Dan-Dan Zhang, Hong Zhang, Yuan-zhi Lao, Rong Wu, Jin-wen Xu, Ferid Murad, Ka Bian*, Hong-Xi Xu*. Anti-Inflammatory Effect of 1,3,5,7-Tetrahydroxy-8-isoprenylxanthone Isolated from Twigs of Garcinia esculenta on Stimulated Macrophage. Mediators Inflamm. 2015; 2015: 350564.
10. Xi Tan, Yuan-Lai Wang, Xiao-Lu Yang, Dan-Dan Zhang*.Ethyl Acetate Extract of Artemisia anomala S. Moore Displays Potent Anti-Inflammatory Effect. Evid Based Complement Alternat Med. 2014; 2014: 681352.
11. Chang-Liang Chen, Dan-Dan Zhang*.Anti-Inflammatory Effects of 81 Chinese Herb Extracts and Their Correlation with the Characteristics of Traditional Chinese Medicine.Evid Based Complement Alternat Med. 2014; 2014: 985176.